Quinomycin C | CAS#11001-74-4

MedKoo Cat#: 462814 | Name: Quinomycin C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinomycin C is an antitumor antibiotic. It removes and reverses the supercoiling of closed circular duplex DNA from bacteriophage PM2 in the fashion characteristic of intercalating drugs.

Chemical Structure

Quinomycin C

CAS#11001-74-4

Theoretical Analysis

MedKoo Cat#: 462814

Name: Quinomycin C

CAS#: 11001-74-4

Chemical Formula: C55H72N12O12S2

Exact Mass: 1156.4834

Molecular Weight: 1157.37

Elemental Analysis: C, 57.08; H, 6.27; N, 14.52; O, 16.59; S, 5.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Antibiotic U 48160; U48160; U 48160; U-48160;

IUPAC/Chemical Name

N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(3-methylbutan-2-yl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane-7,20-diyl)bis(quinoxaline-2-carboxamide)

InChi Key

WNYOPINACXXCOV-UHFFFAOYSA-N

InChi Code

InChI=1S/C55H72N12O12S2/c1-27(2)29(5)42-53(76)78-24-40(63-46(69)38-23-57-34-19-15-17-21-36(34)61-38)48(71)59-32(8)50(73)67(12)44-52(75)66(11)43(30(6)28(3)4)54(77)79-25-39(62-45(68)37-22-56-33-18-14-16-20-35(33)60-37)47(70)58-31(7)49(72)64(9)41(51(74)65(42)10)26-81-55(44)80-13/h14-23,27-32,39-44,55H,24-26H2,1-13H3,(H,58,70)(H,59,71)(H,62,68)(H,63,69)

SMILES Code

CSC1SCC2N(C(C(NC(C(NC(c(cn3)nc4c3cccc4)=O)COC(C(N(C(C1N(C(C(NC(C(NC(c(cn5)nc6c5cccc6)=O)COC(C(N(C2=O)C)C(C(C)C)C)=O)=O)C)=O)C)=O)C)C(C(C)C)C)=O)=O)C)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,157.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Influence of isoleucine upon quinomycin biosynthesis by Streptomyces sp. 732. J Bacteriol. 1967 Apr;93(4):1327-31. doi: 10.1128/JB.93.4.1327-1331.1967. PMID: 6032510; PMCID: PMC276604. 5: Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H. RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening. J Antibiot (Tokyo). 2014 Apr;67(4):323-9. doi: 10.1038/ja.2013.144. Epub 2014 Feb 5. PMID: 24496142. 6: Shoji J, Konaka R, Kawano K, Higuchi N, Kyogoku Y. Presence of isomers in quinomycin E. J Antibiot (Tokyo). 1976 Nov;29(11):1246-8. doi: 10.7164/antibiotics.29.1246. PMID: 993112. 7: Hirose Y, Watanabe K, Minami A, Nakamura T, Oguri H, Oikawa H. Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics. J Antibiot (Tokyo). 2011 Jan;64(1):117-22. doi: 10.1038/ja.2010.142. Epub 2010 Nov 24. PMID: 21102595. 8: Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. J Am Chem Soc. 2009 Jul 8;131(26):9347-53. doi: 10.1021/ja902261a. PMID: 19514719; PMCID: PMC2757413. 9: Searle MS, Wickham G. Hoogsteen versus Watson-Crick A-T basepairing in DNA complexes of a new group of 'quinomycin-like' antibiotics. FEBS Lett. 1990 Oct 15;272(1-2):171-4. doi: 10.1016/0014-5793(90)80476-y. PMID: 2226828. 10: Fox KR. Footprinting studies of the interaction of quinomycin antibiotic UK63052 with DNA: comparison with echinomycin. J Antibiot (Tokyo). 1990 Oct;43(10):1307-15. doi: 10.7164/antibiotics.43.1307. PMID: 2175303. 11: Toda S, Sugawara K, Nishiyama Y, Ohbayashi M, Ohkusa N, Yamamoto H, Konishi M, Oki T. 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