MedKoo Cat#: 562287 | Name: FzM1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

FzM1 is the first allosteric ligand of Frizzled4, a member of the Fzd family of Wnt receptors. It acts by specifically signaling downstream of Wnt5a to promote dendrite branching and growth.

Chemical Structure

FzM1
FzM1
CAS#1680196-54-6

Theoretical Analysis

MedKoo Cat#: 562287

Name: FzM1

CAS#: 1680196-54-6

Chemical Formula: C21H16N2O2S

Exact Mass: 360.0932

Molecular Weight: 360.43

Elemental Analysis: C, 69.98; H, 4.47; N, 7.77; O, 8.88; S, 8.89

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
FzM1; FzM-1; FzM 1; Frizzled M1
IUPAC/Chemical Name
1-(3-Hydroxy-5-(thiophen-2-yl)phenyl)-3-(naphthalen-2-yl)urea
InChi Key
OBTSACXGWYGCPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H16N2O2S/c24-19-12-16(20-6-3-9-26-20)11-18(13-19)23-21(25)22-17-8-7-14-4-1-2-5-15(14)10-17/h1-13,24H,(H2,22,23,25)
SMILES Code
O=C(NC1=CC=C2C=CC=CC2=C1)NC3=CC(C4=CC=CS4)=CC(O)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Riccio G, Bottone S, La Regina G, Badolati N, Passacantilli S, Rossi GB, Accardo A, Dentice M, Silvestri R, Novellino E, Stornaiuolo M. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851. doi: 10.1021/acs.biochem.7b01087. Epub 2018 Jan 19. PubMed PMID: 29293331.