Caspase-6 inhibitor 3a | CAS# | Caspase-6 Inhibitor

MedKoo Cat#: 130552 | Name: Caspase-6 inhibitor 3a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Caspase-6 inhibitor 3a is a novel, irreversible, potent, and selective inhibitor of caspase-6.

Chemical Structure

Caspase-6 inhibitor 3a

CAS#Caspase-6 inhibitor 3a

Theoretical Analysis

MedKoo Cat#: 130552

Name: Caspase-6 inhibitor 3a

CAS#: Caspase-6 inhibitor 3a

Chemical Formula: C21H21F3N2O4S

Exact Mass: 454.1174

Molecular Weight: 454.46

Elemental Analysis: C, 55.50; H, 4.66; F, 12.54; N, 6.16; O, 14.08; S, 7.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Caspase6 inhibitor 3a, Caspase 6 inhibitor 3a, Caspase-6 In 3a, Caspase6 In 3a, Caspase 6 In 3a, Caspase-6-In-3a, Caspase6-In-3a, C6 inhibitor 3a, C6 In 3a, C6-In-3a C6-inhibitor-3a

IUPAC/Chemical Name

(3R,5S)-5-Phenyl-N-(4-(trifluoromethoxy)phenyl)-1-(vinylsulfonyl)piperidine-3-carboxamide

InChi Key

ZPJPZBJLIIKUPK-IAGOWNOFSA-N

InChi Code

InChI=1S/C21H21F3N2O4S/c1-2-31(28,29)26-13-16(15-6-4-3-5-7-15)12-17(14-26)20(27)25-18-8-10-19(11-9-18)30-21(22,23)24/h2-11,16-17H,1,12-14H2,(H,25,27)/t16-,17-/m1/s1

SMILES Code

O=C([C@H]1CN(S(=O)(C=C)=O)C[C@H](C2=CC=CC=C2)C1)NC3=CC=C(OC(F)(F)F)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 454.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J Am Chem Soc. 2023 May 10;145(18):10015-10021. doi: 10.1021/jacs.2c12240. Epub 2023 Apr 27. PMID: 37104712; PMCID: PMC10176470.