MedKoo Cat#: 206128 | Name: Entasobulin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. Entasobulin is a indolizine-glyoxylamide based small molecule that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine).

Chemical Structure

Entasobulin
Entasobulin
CAS#501921-61-5

Theoretical Analysis

MedKoo Cat#: 206128

Name: Entasobulin

CAS#: 501921-61-5

Chemical Formula: C26H18ClN3O2

Exact Mass: 439.1088

Molecular Weight: 439.89

Elemental Analysis: C, 70.99; H, 4.12; Cl, 8.06; N, 9.55; O, 7.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Entasobulin; UNIITB77GU6BFO. Pubchem SID 175427608.
IUPAC/Chemical Name
2-(1-(4-chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(quinolin-6-yl)acetamide.
InChi Key
LJIUXAHLYIPHOK-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H18ClN3O2/c27-19-9-7-17(8-10-19)15-30-16-22(21-5-1-2-6-24(21)30)25(31)26(32)29-20-11-12-23-18(14-20)4-3-13-28-23/h1-14,16H,15H2,(H,29,32)
SMILES Code
O=C(NC1=CC=C2N=CC=CC2=C1)C(C3=CN(CC4=CC=C(Cl)C=C4)C5=C3C=CC=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
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Preparing Stock Solutions

The following data is based on the product molecular weight 439.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: James DA, Koya K, Li H, Liang G, Xia Z, Ying W, Wu Y, Sun L. Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1784-7. doi: 10.1016/j.bmcl.2008.02.029. Epub 2008 Feb 16. PubMed PMID: 18308566.