GRL-0820 | CAS# 2725749-22-2 | SARS-CoV-2 Protease inhibitor

MedKoo Cat#: 121142 | Name: GRL-0820

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GRL-0820 is a SARS-CoV-2 Protease inhibitor (IC50 = 73 nM). GRL-0820 blocked SARS-CoV-2 infection but viral breakthrough occurred.

Chemical Structure

GRL-0820

CAS#2725749-22-2

Theoretical Analysis

MedKoo Cat#: 121142

Name: GRL-0820

CAS#: 2725749-22-2

Chemical Formula: C17H13ClN2O2

Exact Mass: 312.0666

Molecular Weight: 312.75

Elemental Analysis: C, 65.29; H, 4.19; Cl, 11.33; N, 8.96; O, 10.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GRL-0820; GRL0820; GRL 0820

IUPAC/Chemical Name

5-chloropyridin-3-yl 1-allyl-1H-indole-4-carboxylate

InChi Key

XBVPAGLILYEOGS-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H13ClN2O2/c1-2-7-20-8-6-14-15(4-3-5-16(14)20)17(21)22-13-9-12(18)10-19-11-13/h2-6,8-11H,1,7H2

SMILES Code

ClC1=CN=CC(OC(C2=CC=CC3=C2C=CN3CC=C)=O)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 312.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Hattori SI, Higshi-Kuwata N, Raghavaiah J, Das D, Bulut H, Davis DA, Takamatsu Y, Matsuda K, Takamune N, Kishimoto N, Okamura T, Misumi S, Yarchoan R, Maeda K, Ghosh AK, Mitsuya H. GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection. mBio. 2020 Aug 20;11(4):e01833-20. doi: 10.1128/mBio.01833-20. PMID: 32820005; PMCID: PMC7441487.