MedKoo Cat#: 130476 | Name: EIDD-036 prodrug 13L

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EIDD-036 prodrug 13L is a novel pH-responsive water-soluble prodrug of EIDD-036. EIDD-036, also known as EPRX-036, as well as progesterone 20-oxime (P4-20-O) or 20-(hydroxyimino)pregn-4-en-3-one, is a synthetic, water-soluble analogue of progesterone, a neurosteroid, and the active metabolite of EIDD-1723 (EPRX-01723), a medication developed for the potential treatment of traumatic brain injury.

Chemical Structure

EIDD-036 prodrug 13L
EIDD-036 prodrug 13L
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 130476

Name: EIDD-036 prodrug 13L

CAS#: Unknown

Chemical Formula: C28H43N3O3

Exact Mass: 469.3304

Molecular Weight: 469.67

Elemental Analysis: C, 71.61; H, 9.23; N, 8.95; O, 10.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
EIDD-036 prodrug 13; EPRX-036 prodrug;
IUPAC/Chemical Name
(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-17-((E)-1-(((methyl(((S)-pyrrolidin-2-yl)methyl)carbamoyl)oxy)imino)ethyl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
PDMWELPRTMPQBR-NOIOUIOGSA-N
InChi Code
InChI=1S/C28H43N3O3/c1-18(30-34-26(33)31(4)17-20-6-5-15-29-20)23-9-10-24-22-8-7-19-16-21(32)11-13-27(19,2)25(22)12-14-28(23,24)3/h16,20,22-25,29H,5-15,17H2,1-4H3/b30-18+/t20-,22-,23+,24-,25-,27-,28+/m0/s1
SMILES Code
O=C1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H](/C(C)=N/OC(N(C)C[C@H]5NCCC5)=O)CC[C@@]4([H])[C@]3([H])CCC2=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 469.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Fritzemeier RG, van der Westhuyzen AE, D'Erasmo M, Sharma SK, Bartsch P, Hodson LE, Liu K, Wali B, Sayeed I, Liotta DC. Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J Med Chem. 2023 Apr 27;66(8):5397-5414. doi: 10.1021/acs.jmedchem.2c01484. Epub 2023 Apr 7. PMID: 37026870.