Hetrombopag olamine | CAS#1257792-42-9

MedKoo Cat#: 525893 | Name: Hetrombopag olamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hetrombopag olamine is a novel orally bioavailable, non-peptide thrombopoietin (TPO) receptor agonist.

Chemical Structure

Hetrombopag olamine

CAS#1257792-42-9 (olamine)

Theoretical Analysis

MedKoo Cat#: 525893

Name: Hetrombopag olamine

CAS#: 1257792-42-9 (olamine)

Chemical Formula: C27H29N5O6

Exact Mass: 0.0000

Molecular Weight: 519.56

Elemental Analysis: C, 62.42; H, 5.63; N, 13.48; O, 18.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1257792-41-8 (free acid) 1257792-41-8 (ethanolamine) 1257792-42-9 (olamine)

Synonym

Hetrombopag olamine; rafutrombopag olamine

IUPAC/Chemical Name

2-Aminoethanol 5-{2-hydroxy-3-[5-methyl-3-oxo-2-(5,6,7,8-tetrahydro-naphthalen-2-yl)-2,3-dihydro-1H-pyrazol-4-ylazo]-phenyl}-furan-2-carboxylic acid

InChi Key

WPNAPESWZGRRPA-JGUILPGDSA-N

InChi Code

InChI=1S/C25H22N4O5.C2H7NO/c1-14-22(24(31)29(28-14)17-10-9-15-5-2-3-6-16(15)13-17)27-26-19-8-4-7-18(23(19)30)20-11-12-21(34-20)25(32)33;3-1-2-4/h4,7-13,28,30H,2-3,5-6H2,1H3,(H,32,33);4H,1-3H2/b27-26+;

SMILES Code

NCCO.O=C(C1=CC=C(C2=CC=CC(/N=N/C3=C(C)NN(C4=CC=C5CCCCC5=C4)C3=O)=C2O)O1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 519.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xie C, Zhao H, Bao X, Fu H, Lou L. Pharmacological characterization of hetrombopag, a novel orally active human thrombopoietin receptor agonist. J Cell Mol Med. 2018 Nov;22(11):5367-5377. doi: 10.1111/jcmm.13809. Epub 2018 Aug 29. PubMed PMID: 30156363; PubMed Central PMCID: PMC6201220. 2: Zheng L, Liang MZ, Zeng XL, Li CZ, Zhang YF, Chen XY, Zhu X, Xiang AB. Safety, Pharmacokinetics and Pharmacodynamics of Hetrombopag Olamine, a Novel TPO-R Agonist, in Healthy Individuals. Basic Clin Pharmacol Toxicol. 2017 Nov;121(5):414-422. doi: 10.1111/bcpt.12815. Epub 2017 Jun 22. PubMed PMID: 28544774. 3: Zhou N, Wang J, Li X, Zhao Y, Sun Y, Zou C. Hetrombopag, a Thrombopoietin Receptor Agonist, Protects Cardiomyocyte Survival from Oxidative Stress Damage as an Enhancer of Stem Cells. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577. PubMed PMID: 27838864. 4: Chen T, Chen Z, Zhang S, Zhang K, Wang L. Development and validation of a LC-MS/MS method for quantification of hetrombopag for pharmacokinetics study. Springerplus. 2015 Oct 29;4:652. doi: 10.1186/s40064-015-1446-0. eCollection 2015. PubMed PMID: 26543786; PubMed Central PMCID: PMC4628022.