MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 527503 | Name: Hetrombopag Ethanolamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hetrombopag Ethanolamine, also known as SHR-8735, is a thyroperoxidase (TPO) inhibitor potentially for the treatment of thrombocytopenia. Non-peptide small molecular TPO receptor agonists act as enhancers of stem cells in protecting cardiac myocyte survival from oxidative stress damage.

Chemical Structure

Hetrombopag Ethanolamine
Hetrombopag Ethanolamine
CAS#1257792-41-8 (ethanolamine)

Theoretical Analysis

MedKoo Cat#: 527503

Name: Hetrombopag Ethanolamine

CAS#: 1257792-41-8 (ethanolamine)

Chemical Formula: C25H22N4O5

Exact Mass: 0.0000

Molecular Weight: 458.47

Elemental Analysis: C, 65.49; H, 4.84; N, 12.22; O, 17.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
1257792-41-8 (free acid) 1257792-41-8 (ethanolamine) 1257792-42-9 (olamine)
Synonym
HetrombopagEthanolamine; SHR-8735; SHR8735; SHR 8735
IUPAC/Chemical Name
(Z)-5-(2-hydroxy-3-(2-(3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)phenyl)furan-2-carboxylic acid
InChi Key
BDGGFTDRPHKXFC-QYQHSDTDSA-N
InChi Code
InChI=1S/C25H22N4O5/c1-14-22(24(31)29(28-14)17-10-9-15-5-2-3-6-16(15)13-17)27-26-19-8-4-7-18(23(19)30)20-11-12-21(34-20)25(32)33/h4,7-13,26,30H,2-3,5-6H2,1H3,(H,32,33)/b27-22-
SMILES Code
O=C(C1=CC=C(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C5CCCCC5=C4)C/3=O)=C2O)O1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 458.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen T, Chen Z, Zhang S, Zhang K, Wang L. Development and validation of a LC-MS/MS method for quantification of hetrombopag for pharmacokinetics study. Springerplus. 2015 Oct 29;4:652. doi: 10.1186/s40064-015-1446-0. PubMed PMID: 26543786; PubMed Central PMCID: PMC4628022. 2: Zhou N, Wang J, Li X, Zhao Y, Sun Y, Zou C. Hetrombopag, a Thrombopoietin Receptor Agonist, Protects Cardiomyocyte Survival from Oxidative Stress Damage as an Enhancer of Stem Cells. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577. PubMed PMID: 27838864.