KI-696 is a novel chemical probe for KEAP1 and Inhibitor of KEAP1-NRF2 protein-protein interaction. KI-696 represents an excellent LMW tool to study the KEAP1-NRF2 interaction in vivo. Discovered by FBS, the probe is well characterised in a number of in vitro assays as well as showing robust in vivo effects. The in vivo application is hampered by low bioavailability and high clearance, necessitating IV infusions as the mode of administration, which may limit the usefulness of the probe in vivo.
MedKoo Cat#: 407974
Name: KI-696
CAS#: 1799974-70-1
Chemical Formula: C28H30N4O6S
Exact Mass: 550.1886
Molecular Weight: 550.63
Elemental Analysis: C, 61.08; H, 5.49; N, 10.18; O, 17.43; S, 5.82
The following data is based on the product molecular weight 550.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
