GDC-0134 | CAS#1637394-01-4| DLK inhibitor

MedKoo Cat#: 130458 | Name: GDC-0134

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GDC-0134 is a dual leucine zipper kinase (DLK) inhibitor with the ability to penetrate the brain. Inhibition of DLK prevents the degeneration of neurons and blocks the activation of JNK, serving as a potential treatment for ALS. GDC-0134 has undergone a phase 1 study for treating patients with amyotrophic lateral sclerosis (ALS).

Chemical Structure

GDC-0134

CAS#1637394-01-4 (free base)

Theoretical Analysis

MedKoo Cat#: 130458

Name: GDC-0134

CAS#: 1637394-01-4 (free base)

Chemical Formula: C19H20F4N6O2

Exact Mass: 440.1584

Molecular Weight: 440.40

Elemental Analysis: C, 51.82; H, 4.58; F, 17.26; N, 19.08; O, 7.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1637396-55-4 (isomer) 1637394-01-4 (free base) GDC0134 HCl

Synonym

GDC-0134; GDC0134; GDC 0134; RG-6000; RG6000; RG 6000

IUPAC/Chemical Name

5-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-3-(difluoromethoxy)pyridin-2-amine

InChi Key

SKMKJBYBPYBDMN-RYUDHWBXSA-N

InChi Code

InChI=1S/C19H20F4N6O2/c20-17(21)31-14-3-10(6-25-16(14)24)13-5-15(29-7-12-4-11(29)8-30-12)27-18(26-13)28-2-1-19(22,23)9-28/h3,5-6,11-12,17H,1-2,4,7-9H2,(H2,24,25)/t11-,12-/m0/s1

SMILES Code

NC1=NC=C(C2=NC(N3CC(F)(F)CC3)=NC(N4[C@]5([H])CO[C@](C5)([H])C4)=C2)C=C1OC(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 440.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Katz JS, Rothstein JD, Cudkowicz ME, Genge A, Oskarsson B, Hains AB, Chen C, Galanter J, Burgess BL, Cho W, Kerchner GA, Yeh FL, Ghosh AS, Cheeti S, Brooks L, Honigberg L, Couch JA, Rothenberg ME, Brunstein F, Sharma KR, van den Berg L, Berry JD, Glass JD. A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. Ann Clin Transl Neurol. 2022 Jan;9(1):50-66. doi: 10.1002/acn3.51491. Epub 2022 Jan 10. PMID: 35014217; PMCID: PMC8791798. 2. https://genentech-clinicaltrials.com/en/trials/neurodegenerative-disorder/als/a-study-of-gdc-0134-to-determine-initial-safety--tolerability--a.html