MedKoo Cat#: 130437 | Name: SLU-PP-332
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLU-PP-332, a ERR pan agonist with the highest affinity for ERRα, has been shown to lead to the increase of mitochondrial function and cellular respiration in a specific skeletal muscle cell line. SLU-PP-332 paves the way for the development of new molecules targeting the ERRα for the treatment of metabolic disorder and serving as a way to improve muscle function in aging.

Chemical Structure

SLU-PP-332
CAS#303760-60-3

Theoretical Analysis

MedKoo Cat#: 130437

Name: SLU-PP-332

CAS#: 303760-60-3

Chemical Formula: C18H14N2O2

Exact Mass: 290.1055

Molecular Weight: 290.32

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 74.47; H, 4.86; N, 9.65; O, 11.02

Price and Availability

Size Price Availability Quantity
10mg USD 90.00 Ready to ship
25mg USD 150.00 Ready to ship
50mg USD 250.00 Ready to ship
100mg USD 450.00 Ready to ship
200mg USD 750.00 Ready to ship
500mg USD 1,650.00 Ready to ship
1g USD 2,950.00 Ready to ship
2g USD 5,250.00 Ready to ship
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Related CAS #
No Data
Synonym
SLU-PP-332; SLU PP 332
IUPAC/Chemical Name
(E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
InChi Key
RNZIMBFHRXYRLL-XDHOZWIPSA-N
InChi Code
InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12+
SMILES Code
O=C(N/N=C/C1=CC=C2C=CC=CC2=C1)C3=CC=C(O)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
SLU-PP-332 is a pan- ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines.
In vitro activity:
To be determined
In vivo activity:
SLU-PP-332, may offer a promising approach for treating metabolic syndrome and obesity. When administered to diet-induced obese or ob/ob mice, SLU-PP-332 mimicked the beneficial effects of exercise, leading to increased energy expenditure, enhanced fatty acid oxidation, and reduced fat mass accumulation. Furthermore, it improved insulin sensitivity in models of metabolic syndrome. Reference: J Pharmacol Exp Ther. 2023 Sep 22:JPET-AR-2023-001733. https://pubmed.ncbi.nlm.nih.gov/37739806/

Preparing Stock Solutions

The following data is based on the product molecular weight 290.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2023 Sep 22:JPET-AR-2023-001733. doi: 10.1124/jpet.123.001733. Epub ahead of print. PMID: 37739806. 2. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910.
In vitro protocol:
To be determined
In vivo protocol:
1. Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2023 Sep 22:JPET-AR-2023-001733. doi: 10.1124/jpet.123.001733. Epub ahead of print. PMID: 37739806. 2. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910.
1. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910. 2. https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.9682 3. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM4663186