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MedKoo Cat#: 591293 | Name: Perflexane
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perflexane was developed as an ultrasound (US) contrast agent for use in echocardiograms to enhance US images.

Chemical Structure

Perflexane
Perflexane
CAS#355-42-0

Theoretical Analysis

MedKoo Cat#: 591293

Name: Perflexane

CAS#: 355-42-0

Chemical Formula: C6F14

Exact Mass: 337.9776

Molecular Weight: 338.04

Elemental Analysis: C, 21.32; F, 78.68

Price and Availability

Size Price Availability Quantity
25g USD 250.00
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Related CAS #
No Data
Synonym
Perflexane; Fluorinert FC72;
IUPAC/Chemical Name
Hexane, tetradecafluoro-
InChi Key
ZJIJAJXFLBMLCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C6F14/c7-1(8,3(11,12)5(15,16)17)2(9,10)4(13,14)6(18,19)20
SMILES Code
FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Perflexane was developed as an ultrasound (US) contrast agent for use in echocardiograms to enhance US images.
In vitro activity:
To further enhance the selective tumor targeting ability of Cur-loaded NCs, a novel CS/PFH-Cur-NCs (cur-loaded chitosan/perfluorohexane) with conjugation of Arg-Gly-Asp (RGD) peptide (RGD-CS/PFH-Cur-NCs) were prepared in this study. It was found that both CS/PFH-Cur-NCs and RGD-CS/PFH-Cur-NCs were smooth, relatively uniform, spheroid particles, with the latter being 531.20 ± 68.97 nm in size. These RGD-CS/PFH-Cur-NCs can be ideal for contrast imaging studies, and were better able to target breast cancer cells in comparison to CS/PFH-Cur-NCs. In addition, RGD-CS/PFH-Cur-NCs were observed to induce cytotoxic MDA-MB-231 cell death more swiftly in comparison to CS/PFH-Cur-NCs. Reference: Heliyon. 2022 Jul 11;8(7):e09931. https://pubmed.ncbi.nlm.nih.gov/35865990/
In vivo activity:
In this study, folic acid-functionalized methotrexate-loaded perfluorohexane NDs with alginate shell (FA-MTX/PFH@alginate NDs) were synthesized, characterized, and their potential for ultrasound-guided chemoradiotherapy of breast cancer was investigated in vitro and in vivo. Furthermore, the in vivo results indicated that the FA-MTX/PFH@alginate NDs were accumulated selectively in the tumor region. Reference: Nanomedicine. 2023 Feb;48:102643. https://pubmed.ncbi.nlm.nih.gov/36584739/

Preparing Stock Solutions

The following data is based on the product molecular weight 338.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang L, Zhu S, Zou C, Kou H, Xu M, Li J. Preparation and evaluation of the anti-cancer properties of RGD-modified curcumin-loaded chitosan/perfluorohexane nanocapsules in vitro. Heliyon. 2022 Jul 11;8(7):e09931. doi: 10.1016/j.heliyon.2022.e09931. PMID: 35865990; PMCID: PMC9294197. 2. Maghsoudinia F, Akbari-Zadeh H, Aminolroayaei F, Birgani FF, Shanei A, Samani RK. Ultrasound responsive Gd-DOTA/doxorubicin-loaded nanodroplet as a theranostic agent for magnetic resonance image-guided controlled release drug delivery of melanoma cancer. Eur J Pharm Sci. 2022 Jul 1;174:106207. doi: 10.1016/j.ejps.2022.106207. Epub 2022 May 13. PMID: 35577179. 3. Samani RK, Maghsoudinia F, Mehradnia F, Hejazi SH, Saeb M, Sobhani T, Farahbakhsh Z, Mehrgardi MA, Tavakoli MB. Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets. Nanomedicine. 2023 Feb;48:102643. doi: 10.1016/j.nano.2022.102643. Epub 2022 Dec 28. PMID: 36584739. 4. Sim KH, Lee YJ. Perfluorohexane sulfonate induces memory impairment and downregulation of neuroproteins via NMDA receptor-mediated PKC-ERK/AMPK signaling pathway. Chemosphere. 2022 Feb;288(Pt 1):132503. doi: 10.1016/j.chemosphere.2021.132503. Epub 2021 Oct 7. PMID: 34626661.
In vitro protocol:
1. Wang L, Zhu S, Zou C, Kou H, Xu M, Li J. Preparation and evaluation of the anti-cancer properties of RGD-modified curcumin-loaded chitosan/perfluorohexane nanocapsules in vitro. Heliyon. 2022 Jul 11;8(7):e09931. doi: 10.1016/j.heliyon.2022.e09931. PMID: 35865990; PMCID: PMC9294197. 2. Maghsoudinia F, Akbari-Zadeh H, Aminolroayaei F, Birgani FF, Shanei A, Samani RK. Ultrasound responsive Gd-DOTA/doxorubicin-loaded nanodroplet as a theranostic agent for magnetic resonance image-guided controlled release drug delivery of melanoma cancer. Eur J Pharm Sci. 2022 Jul 1;174:106207. doi: 10.1016/j.ejps.2022.106207. Epub 2022 May 13. PMID: 35577179.
In vivo protocol:
1. Samani RK, Maghsoudinia F, Mehradnia F, Hejazi SH, Saeb M, Sobhani T, Farahbakhsh Z, Mehrgardi MA, Tavakoli MB. Ultrasound-guided chemoradiotherapy of breast cancer using smart methotrexate-loaded perfluorohexane nanodroplets. Nanomedicine. 2023 Feb;48:102643. doi: 10.1016/j.nano.2022.102643. Epub 2022 Dec 28. PMID: 36584739. 2. Sim KH, Lee YJ. Perfluorohexane sulfonate induces memory impairment and downregulation of neuroproteins via NMDA receptor-mediated PKC-ERK/AMPK signaling pathway. Chemosphere. 2022 Feb;288(Pt 1):132503. doi: 10.1016/j.chemosphere.2021.132503. Epub 2021 Oct 7. PMID: 34626661.
1. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.