NUN36778, also known as Pomalidomide-C9-NH2 hydrochloride is a vital component in the synthesis of protein degraders and PROTACs. The conjugate consists of a Cereblon (CRBN)-recruiting ligand, a rigid linker, and a pendant amine. The pendant amine of the conjugate reacts with the carboxylic acid of the target ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 130383
Name: NUN36778
CAS#: 2305936-77-8
Chemical Formula: C22H31ClN4O4
Exact Mass: 0.0000
Molecular Weight: 450.96
Elemental Analysis: C, 58.59; H, 6.93; Cl, 7.86; N, 12.42; O, 14.19
The following data is based on the product molecular weight 450.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
