Nusinersen | CAS# 1258984-36-9 | Antisense Oligonucleotide

MedKoo Cat#: 575066 | Name: Nusinersen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nusinersen is an antisense oligonucleotide that induces SMN protein expression. Nusinersen was developed in 2016 for the treatment of spinal muscular atrophy (SMA), a rare neuromuscular disorder.

Chemical Structure

Nusinersen

CAS#1258984-36-9

Theoretical Analysis

MedKoo Cat#: 575066

Name: Nusinersen

CAS#: 1258984-36-9

Chemical Formula: C234H340N61O128P17S17

Exact Mass: 7122.2762

Molecular Weight: 7127.17

Elemental Analysis: C, 39.43; H, 4.81; N, 11.99; O, 28.73; P, 7.39; S, 7.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ASO-10-27; ISIS 396443; ISIS SMNRx; Nusinersen

IUPAC/Chemical Name

RNA, (2'-0-(2-methoxyethyi))(p-thio)(m5u-c-a-c-m5u-m5u-m5u-c-a-m5ua- a-m5 u-g-c-m5u-g-g)

InChi Key

WWFDJIVIDXJAQR-FFWSQMGZSA-N

InChi Code

InChI=1S/C234H340N61O128P17S17/c1-106-66-278(224(308)261-178(106)235)205-162(356-50-32-338-14)144(119(391-205)79-373-425(320,442)407-143-117(77-296)389-204(161(143)355-49-31-337-13)282-70-110(5)193(298)271-228(282)312)410-431(326,448)383-89-129-154(172(366-60-42-348-24)215(401-129)289-99-254-135-182(239)246-95-250-186(135)289)419-436(331,453)379-81-121-145(163(357-51-33-339-15)206(393-121)279-67-107(2)179(236)262-225(279)309)408-426(321,443)375-83-123-149(167(361-55-37-343-19)210(395-123)284-72-112(7)195(300)273-230(284)314)413-429(324,446)378-86-125-150(168(362-56-38-344-20)211(397-125)285-73-113(8)196(301)274-231(285)315)414-430(325,447)377-85-124-148(166(360-54-36-342-18)209(396-124)283-71-111(6)194(299)272-229(283)313)412-428(323,445)374-80-120-147(165(359-53-35-341-17)208(392-120)281-69-109(4)181(238)264-227(281)311)411-432(327,449)384-90-130-155(173(367-61-43-349-25)216(402-130)290-100-255-136-183(240)247-96-251-187(136)290)420-437(332,454)381-87-127-152(170(364-58-40-346-22)213(399-127)287-75-115(10)198(303)276-233(287)317)415-433(328,450)385-91-131-157(175(369-63-45-351-27)218(403-131)292-102-257-138-185(242)249-98-253-189(138)292)422-440(335,457)386-92-132-156(174(368-62-44-350-26)217(404-132)291-101-256-137-184(241)248-97-252-188(137)291)421-438(333,455)382-88-128-153(171(365-59-41-347-23)214(400-128)288-76-116(11)199(304)277-234(288)318)417-435(330,452)388-94-134-159(177(371-65-47-353-29)220(406-134)295-105-260-141-192(295)267-223(245)270-202(141)307)423-439(334,456)380-82-122-146(164(358-52-34-340-16)207(394-122)280-68-108(3)180(237)263-226(280)310)409-427(322,444)376-84-126-151(169(363-57-39-345-21)212(398-126)286-74-114(9)197(302)275-232(286)316)416-434(329,451)387-93-133-158(176(370-64-46-352-28)219(405-133)294-104-259-140-191(294)266-222(244)269-201(140)306)418-424(319,441)372-78-118-142(297)160(354-48-30-336-12)203(390-118)293-103-258-139-190(293)265-221(243)268-200(139)305/h66-76,95-105,117-134,142-177,203-220,296-297H,30-65,77-94H2,1-29H3,(H,319,441)(H,320,442)(H,321,443)(H,322,444)(H,323,445)(H,324,446)(H,325,447)(H,326,448)(H,327,449)(H,328,450)(H,329,451)(H,330,452)(H,331,453)(H,332,454)(H,333,455)(H,334,456)(H,335,457)(H2,235,261,308)(H2,236,262,309)(H2,237,263,310)(H2,238,264,311)(H2,239,246,250)(H2,240,247,251)(H2,241,248,252)(H2,242,249,253)(H,271,298,312)(H,272,299,313)(H,273,300,314)(H,274,301,315)(H,275,302,316)(H,276,303,317)(H,277,304,318)(H3,243,265,268,305)(H3,244,266,269,306)(H3,245,267,270,307)/t117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,203-,204-,205-,206-,207-,208-,209-,210-,211-,212-,213-,214-,215-,216-,217-,218-,219-,220-,424?,425?,426?,427?,428?,429?,430?,431?,432?,433?,434?,435?,436?,437?,438?,439?,440?/m1/s1

SMILES Code

COCCO[C@@H]1[C@H](O)[C@@H](COP(=S)(O)O[C@@H]2[C@@H](COP(=O)(S)O[C@@H]3[C@@H](COP(=S)(O)O[C@@H]4[C@@H](COP(=S)(O)O[C@@H]5[C@@H](COP(=S)(O)O[C@@H]6[C@@H](COP(=S)(O)O[C@@H]7[C@@H](COP(=S)(O)O[C@@H]8[C@@H](COP(=S)(O)O[C@@H]9[C@@H](COP(=S)(O)O[C@@H]%10[C@@H](COP(=S)(O)O[C@@H]%11[C@@H](COP(=S)(O)O[C@@H]%12[C@@H](COP(=S)(O)O[C@@H]%13[C@@H](COP(=S)(O)O[C@@H]%14[C@@H](COP(=S)(O)O[C@@H]%15[C@@H](COP(=S)(O)O[C@@H]%16[C@@H](COP(=S)(O)O[C@@H]%17[C@@H](COP(=S)(O)O[C@@H]%18[C@@H](CO)O[C@H]([C@@H]%18OCCOC)N%19C=C(C)C(=O)NC%19=O)O[C@H]([C@@H]%17OCCOC)N%20C=C(C)C(=NC%20=O)N)O[C@H]([C@@H]%16OCCOC)n%21cnc%22c(N)ncnc%21%22)O[C@H]([C@@H]%15OCCOC)N%23C=C(C)C(=NC%23=O)N)O[C@H]([C@@H]%14OCCOC)N%24C=C(C)C(=O)NC%24=O)O[C@H]([C@@H]%13OCCOC)N%25C=C(C)C(=O)NC%25=O)O[C@H]([C@@H]%12OCCOC)N%26C=C(C)C(=O)NC%26=O)O[C@H]([C@@H]%11OCCOC)N%27C=C(C)C(=NC%27=O)N)O[C@H]([C@@H]%10OCCOC)n%28cnc%29c(N)ncnc%28%29)O[C@H]([C@@H]9OCCOC)N%30C=C(C)C(=O)NC%30=O)O[C@H]([C@@H]8OCCOC)n%31cnc%32c(N)ncnc%31%32)O[C@H]([C@@H]7OCCOC)n%33cnc%34c(N)ncnc%33%34)O[C@H]([C@@H]6OCCOC)N%35C=C(C)C(=O)NC%35=O)O[C@H]([C@@H]5OCCOC)n%36cnc%37C(=O)NC(=Nc%36%37)N)O[C@H]([C@@H]4OCCOC)N%38C=C(C)C(=NC%38=O)N)O[C@H]([C@@H]3OCCOC)N%39C=C(C)C(=O)NC%39=O)O[C@H]([C@@H]2OCCOC)n%40cnc%41C(=O)NC(=Nc%40%41)N)O[C@H]1n%42cnc%43C(=O)NC(=Nc%42%43)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 7,127.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Chiriboga CA. Nusinersen for the treatment of spinal muscular atrophy. Expert Rev Neurother. 2017 Oct;17(10):955-962. doi: 10.1080/14737175.2017.1364159. Epub 2017 Sep 8. PMID: 28884620. 2. Claborn MK, Stevens DL, Walker CK, Gildon BL. Nusinersen: A Treatment for Spinal Muscular Atrophy. Ann Pharmacother. 2019 Jan;53(1):61-69. doi: 10.1177/1060028018789956. Epub 2018 Jul 16. PMID: 30008228.