T0510-3657 | CAS#523983-93-9 | GPR17 activator

MedKoo Cat#: 130155 | Name: T0510-3657

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T0510-3657 is a selective activator of GPR17, inhibiting cAMP levels, with potential for playing a key role in the development of a treatment against diseases such as, multiple sclerosis, Parkinson disease, Alzheimer's disease, and cancer.

Chemical Structure

T0510-3657

CAS#523983-93-9

Theoretical Analysis

MedKoo Cat#: 130155

Name: T0510-3657

CAS#: 523983-93-9

Chemical Formula: C30H30F3N5O5S2

Exact Mass: 661.1640

Molecular Weight: 661.72

Elemental Analysis: C, 54.45; H, 4.57; F, 8.61; N, 10.58; O, 12.09; S, 9.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

T0510-3657; T0510 3657; T0510.3657

IUPAC/Chemical Name

N-(4-isopropylphenyl)-2-((5-(3-(morpholinosulfonyl)phenyl)-4-(4-(trifluoromethoxy)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetamide

InChi Key

UENHMSTYHNSINA-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H30F3N5O5S2/c1-20(2)21-6-8-23(9-7-21)34-27(39)19-44-29-36-35-28(38(29)24-10-12-25(13-11-24)43-30(31,32)33)22-4-3-5-26(18-22)45(40,41)37-14-16-42-17-15-37/h3-13,18,20H,14-17,19H2,1-2H3,(H,34,39)

SMILES Code

O=C(NC1=CC=C(C(C)C)C=C1)CSC2=NN=C(C3=CC=CC(S(=O)(N4CCOCC4)=O)=C3)N2C5=CC=C(OC(F)(F)F)C=C5

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 661.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Konda Mani S, Thiyagarajan R, Yli-Harja O, Kandhavelu M, Murugesan A. Structural analysis of human G-protein-coupled receptor 17 ligand binding sites. J Cell Biochem. 2023 Feb 15. doi: 10.1002/jcb.30388. Epub ahead of print. PMID: 36791278. 2. Murugesan A, Nguyen P, Ramesh T, Yli-Harja O, Kandhavelu M, Saravanan KM. Molecular modeling and dynamics studies of the synthetic small molecule agonists with GPR17 and P2Y1 receptor. J Biomol Struct Dyn. 2022;40(23):12908-12916. doi: 10.1080/07391102.2021.1977707. Epub 2021 Sep 20. PMID: 34542380. 3. Doan P, Nguyen P, Murugesan A, Candeias NR, Yli-Harja O, Kandhavelu M. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. doi: 10.3390/cells10081975. PMID: 34440745; PMCID: PMC8393831. 4. Saravanan KM, Palanivel S, Yli-Harja O, Kandhavelu M. Identification of novel GPR17-agonists by structural bioinformatics and signaling activation. Int J Biol Macromol. 2018 Jan;106:901-907. doi: 10.1016/j.ijbiomac.2017.08.088. Epub 2017 Aug 18. PMID: 28827203.