KISS1 305 | CAS# 872717-97-0 | Kisspeptin1 receptor agonist

MedKoo Cat#: 123026 | Name: KISS1 305

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

KISS1 305 is a potent Kisspeptin1 receptor agonist.

Chemical Structure

KISS1 305

CAS#872717-97-0 (free base)

Theoretical Analysis

MedKoo Cat#: 123026

Name: KISS1 305

CAS#: 872717-97-0 (free base)

Chemical Formula: C56H76N16O12

Exact Mass: 1164.5800

Molecular Weight: 1165.32

Elemental Analysis: C, 57.72; H, 6.57; N, 19.23; O, 16.48

Price and Availability

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1mg	USD 650.00	2 Weeks

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Related CAS #

872717-97-0 (free base) KISS1-305 (trifluoroacetate salt)

Synonym

KISS1 305; KISS1-305; CHEMBL3086284; Tp-005; HY-P2191; BDBM50442961

IUPAC/Chemical Name

(S)-N1-((8S,11S,17S,20S)-8-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-17-benzyl-21-hydroxy-3-imino-11-isobutyl-10,13,16,19-tetraoxo-2,4,9,12,14,15,18-heptaazahenicosan-20-yl)-2-((R)-2-((R)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-(pyridin-4-yl)propanamido)succinamide

InChi Key

YSVWFFNZZGLLAI-XNTOLAJGSA-N

InChi Code

InChI=1S/C56H76N16O12/c1-32(2)25-41(50(79)64-39(15-10-22-63-55(60)61-3)49(78)65-40(47(59)76)27-33-11-6-4-7-12-33)70-56(84)72-71-54(83)43(28-34-13-8-5-9-14-34)67-53(82)45(31-73)69-52(81)44(30-46(58)75)68-51(80)42(29-36-20-23-62-24-21-36)66-48(77)38(57)26-35-16-18-37(74)19-17-35/h4-9,11-14,16-21,23-24,32,38-45,73-74H,10,15,22,25-31,57H2,1-3H3,(H2,58,75)(H2,59,76)(H,64,79)(H,65,78)(H,66,77)(H,67,82)(H,68,80)(H,69,81)(H,71,83)(H3,60,61,63)(H2,70,72,84)/t38-,39+,40+,41+,42-,43+,44+,45+/m1/s1

SMILES Code

O=C(N[C@@H](CCCNC(NC)=N)C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)[C@H](CC(C)C)NC(NNC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](NC([C@@H](CC3=CC=C(C=C3)O)N)=O)CC4=CC=NC=C4)=O)=O)=O)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,165.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Matsui H, Tanaka A, Yokoyama K, Takatsu Y, Ishikawa K, Asami T, Nishizawa N, Suzuki A, Kumano S, Terada M, Kusaka M, Kitada C, Ohtaki T. Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats. Endocrinology. 2012 Nov;153(11):5297-308. doi: 10.1210/en.2012-1388. Epub 2012 Oct 1. PMID: 23027808.