NSC321039, also known as hMAO-B-IN-4, is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value of 0.067 μM. This compound was reported in Scientific Reports (2022), 12(1), 22404 NSC321039 was reversible inhibitor of hMAO-B. PAMPA assay manifested that NSC321039 had a significant permeability and CNS bioavailability with Pe value higher than 4.0 x 10-6 cm/s. NSC321039 was stabilized in protein-ligand complexes by the π-π stacking, which enabled them to bind to the hMAO-B enzyme′s active site incredibly effectively.
MedKoo Cat#: 556205
Name: NSC321039
CAS#: 1666119-75-0
Chemical Formula: C20H16O2S
Exact Mass: 320.0871
Molecular Weight: 320.41
Elemental Analysis: C, 74.97; H, 5.03; O, 9.99; S, 10.01
The following data is based on the product molecular weight 320.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
