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MedKoo Cat#: 130274 | Name: L-Moses dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Moses dihydrochloride is a PCAF bromodomain inhibitor.

Chemical Structure

L-Moses dihydrochloride
L-Moses dihydrochloride
CAS#2079885-05-3 (free base)

Theoretical Analysis

MedKoo Cat#: 130274

Name: L-Moses dihydrochloride

CAS#: 2079885-05-3 (free base)

Chemical Formula: C21H26Cl2N6

Exact Mass: 432.1596

Molecular Weight: 433.38

Elemental Analysis: C, 58.20; H, 6.05; Cl, 16.36; N, 19.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
L-45 dihydrochloride; L-Moses dihydrochloride
IUPAC/Chemical Name
(1S,2S)-N1,N1-dimethyl-N2-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
InChi Key
PCQCTBXCEBIRAC-YRRRDGBXSA-N
InChi Code
InChI=1S/C21H24N6.2ClH/c1-14(19(26(3)4)16-10-6-5-7-11-16)22-20-17-12-8-9-13-18(17)21-24-23-15(2)27(21)25-20;;/h5-14,19H,1-4H3,(H,22,25);2*1H/t14-,19+;;/m0../s1
SMILES Code
C[C@H](NC(C1=C2C=CC=C1)=NN3C2=NN=C3C)[C@H](C4=CC=CC=C4)N(C)C.[H]Cl.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1 : Pavlou S, Foskolou S, Patikas N, Field SF, Papachristou EK, Santos C, Edwards AR, Kishore K, Ansari R, Rajan SS, Fernandes HJR, Metzakopian E. CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci Rep. 2023 Mar 9;13(1):3934. doi: 10.1038/s41598-023-31141-6. PMID: 36894612; PMCID: PMC9998435. 2: Hanquier J, Gimeno T, Jeffers V, Sullivan WJ Jr. Evaluating the GCN5b bromodomain as a novel therapeutic target against the parasite Toxoplasma gondii. Exp Parasitol. 2020 Feb 28;211:107868. doi: 10.1016/j.exppara.2020.107868. Epub ahead of print. PMID: 32119930; PMCID: PMC7483680. 3: Moustakim M, Clark PG, Trulli L, Fuentes de Arriba AL, Ehebauer MT, Chaikuad A, Murphy EJ, Mendez-Johnson J, Daniels D, Hou CD, Lin YH, Walker JR, Hui R, Yang H, Dorrell L, Rogers CM, Monteiro OP, Fedorov O, Huber KV, Knapp S, Heer J, Dixon DJ, Brennan PE. Discovery of a PCAF Bromodomain Chemical Probe. Angew Chem Int Ed Engl. 2017 Jan 16;56(3):827-831. doi: 10.1002/anie.201610816. Epub 2016 Dec 14. PMID: 27966810; PMCID: PMC5412877. 4: Fernandez-Moure JS, Moses ML, Garcia A, Reader MM. An unusual presentation of congenital intestinal malrotation in a nonagenarian. Int J Surg Case Rep. 2016;25:229-33. doi: 10.1016/j.ijscr.2016.06.053. Epub 2016 Jul 1. PMID: 27399168; PMCID: PMC4941200. 5: Lyman GH, Moses HL. Biomarker Tests for Molecularly Targeted Therapies: Laying the Foundation and Fulfilling the Dream. J Clin Oncol. 2016 Jun 10;34(17):2061-6. doi: 10.1200/JCO.2016.67.3160. Epub 2016 Apr 11. PMID: 27069080. 6: Moses PL, Alnaamani KM, Barkun AN, Gordon SR, Mitty RD, Branch MS, Kowalski TE, Martel M, Adam V. Randomized trial in malignant biliary obstruction: plastic vs partially covered metal stents. World J Gastroenterol. 2013 Dec 14;19(46):8638-46. doi: 10.3748/wjg.v19.i46.8638. PMID: 24379581; PMCID: PMC3870509. 7: Costedio MM, Coates MD, Brooks EM, Glass LM, Ganguly EK, Blaszyk H, Ciolino AL, Wood MJ, Strader D, Hyman NH, Moses PL, Mawe GM. Mucosal serotonin signaling is altered in chronic constipation but not in opiate-induced constipation. Am J Gastroenterol. 2010 May;105(5):1173-80. doi: 10.1038/ajg.2009.683. Epub 2009 Dec 15. PMID: 20010921; PMCID: PMC2872481. 8: Wu SP, Theodorescu D, Kerbel RS, Willson JK, Mulder KM, Humphrey LE, Brattain MG. TGF-beta 1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vector. J Cell Biol. 1992 Jan;116(1):187-96. doi: 10.1083/jcb.116.1.187. PMID: 1730743; PMCID: PMC2289262. 9: Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB. Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution. J Clin Invest. 1990 Dec;86(6):1976-84. doi: 10.1172/JCI114932. PMID: 2254455; PMCID: PMC329834. 10: Holley RW, Baldwin JH, Greenfield S, Armour R. A growth regulatory factor that can both inhibit and stimulate growth. Ciba Found Symp. 1985;116:241-52. doi: 10.1002/9780470720974.ch15. PMID: 3878272.