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MedKoo Cat#: 592974 | Name: Tribromsalan
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tribromsalan is a Germicide compound with potential in applications inhibiting bacteria responsible for tuberculosis.

Chemical Structure

Tribromsalan
Tribromsalan
CAS# 87-10-5

Theoretical Analysis

MedKoo Cat#: 592974

Name: Tribromsalan

CAS#: 87-10-5

Chemical Formula: C13H8Br3NO2

Exact Mass: 446.8105

Molecular Weight: 449.92

Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 34.70; H, 1.79; Br, 53.28; N, 3.11; O, 7.11

Price and Availability

Size Price Availability Quantity
25g USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Agramed, AI3-25516, ASC-4, BRN 2146888, Caswell No. 863, CCRIS 5745, ENT 25516, EPA Pesticide Chemical Code 077404, ET-394, Sherstat TBS, Stecker asc-4, TBS, TBS 95, Tribromsalan, Temasept II, Temasept IV, Tribromosalicylanilide, Trisanil, Tuasol 100, Vancide TBS, WR 34912
IUPAC/Chemical Name
3,5-Dibromo-N-(4-bromophenyl)-2-hydroxybenzamide
InChi Key
KVSKGMLNBAPGKH-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8Br3NO2/c14-7-1-3-9(4-2-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)
SMILES Code
O=C(NC1=CC=C(Br)C=C1)C2=CC(Br)=CC(Br)=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 449.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang JJ, Goff A, Wild DJ, Ding Y, Annis A, Kerber R, Foote B, Passi A, Duerksen JL, London S, Puhl AC, Lane TR, Braunstein M, Waddell SJ, Ekins S. Computational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus. Tuberculosis (Edinb). 2024 May;146:102500. doi: 10.1016/j.tube.2024.102500. Epub 2024 Feb 27. PMID: 38432118; PMCID: PMC10978224. 2: Sakamoto M, Takeba K, Sasamoto T, Kusano T, Hayashi H, Kanai S, Kanda M, Nagayama T. Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry. J AOAC Int. 2010 Jul-Aug;93(4):1340-6. PMID: 20922970. 3: Miller SC, Huang R, Sakamuru S, Shukla SJ, Attene-Ramos MS, Shinn P, Van Leer D, Leister W, Austin CP, Xia M. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol. 2010 May 1;79(9):1272-80. doi: 10.1016/j.bcp.2009.12.021. Epub 2010 Jan 11. PMID: 20067776; PMCID: PMC2834878. 4: Fujinuma K, Takeba K, Kamata K. [Concentration in plasma and excretion in milk of lactating cows after oral administration of tribromsalan, oxyclozanide and bromofenofos]. Shokuhin Eiseigaku Zasshi. 2006 Dec;47(6):249-53. Japanese. doi: 10.3358/shokueishi.47.249. PMID: 17228788. 5: Durbize E, Vigan M, Puzenat E, Girardin P, Adessi B, Desprez PH, Humbert PH, Laurent R, Aubin F. Spectrum of cross-photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen: associated photoallergies to non-benzophenone-containing molecules. Contact Dermatitis. 2003 Mar;48(3):144-9. doi: 10.1034/j.1600-0536.2003.00066.x. PMID: 12755728. 6: Takeba K, Itoh T, Matsumoto M, Nakazawa H, Tanabe S. Simultaneous determination of five fasciolicides in milk by liquid chromatography with electrochemical detection. J AOAC Int. 1996 Jul-Aug;79(4):848-52. PMID: 8757441. 7: Vohr HW, Homey B, Schuppe HC, Kind P. Detection of photoreactivity demonstrated in a modified local lymph node assay in mice. Photodermatol Photoimmunol Photomed. 1994 Apr;10(2):57-64. PMID: 8043386. 8: Xia Q, Tan P, Feng X, Chen M, Kajihara N, Minai M, Hosaka Y. Assessment of the molluscicidal activities of Tribromosalan, Cartap and Chlorothalonil against Oncomelania hupensis. Jpn J Med Sci Biol. 1992 Apr;45(2):75-80. doi: 10.7883/yoken1952.45.75. PMID: 1434068. 9: Miyauchi H, Horio T. A new animal model for contact dermatitis: the hairless guinea pig. J Dermatol. 1992 Mar;19(3):140-5. doi: 10.1111/j.1346-8138.1992.tb03197.x. PMID: 1640019. 10: Duschet P, Schwarz T, Oppolzer G, Gschnait F. Persistent light reaction. Successful treatment with cyclosporin A. Acta Derm Venereol. 1988;68(2):176-8. PMID: 2454004. 11: Yoshimura H, Nakamura M, Koeda T. Lack of mutagenicity of fasciolicides. Vet Res Commun. 1985 Apr;9(2):147-52. doi: 10.1007/BF02215138. PMID: 4002614. 12: Miyachi Y, Takigawa M. Mechanisms of contact photosensitivity in mice. III. Predictive testing of chemicals with photoallergenic potential in mice. Arch Dermatol. 1983 Sep;119(9):736-9. PMID: 6614960. 13: Horio T. Actinic reticuloid via persistent light reaction from photoallergic contact dermatitis. Arch Dermatol. 1982 May;118(5):339-42. PMID: 7082027. 14: Jordan WP Jr. The guinea pig as a model for predicting photoallergic contact dermatitis. Contact Dermatitis. 1982 Mar;8(2):109-16. doi: 10.1111/j.1600-0536.1982.tb04155.x. PMID: 7067446. 15: De Vries H, Beijersbergen van Henegouwen GM. The influence of glutathione on the photoreaction of 3,4',5-tribromosalicylanilide alone and in the presence of serum albumin. Pharm Weekbl Sci. 1981 Dec 18;3(6):258-62. PMID: 7329770. 16: Coburn RA, Batista AJ, Evans RT, Genco RJ. Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus. J Med Chem. 1981 Oct;24(10):1245-9. doi: 10.1021/jm00142a023. PMID: 7328586. 17: Norbury HM, Waring RH. The disposition and metabolism of 3,4',5-tribromosalicylanilide and 4'5-dibromosalicylanilide in the rat. Xenobiotica. 1981 Jul;11(7):501-8. doi: 10.3109/00498258109045860. PMID: 7293237. 18: Cruthers LR, James TM, Goff S. Efficacy of a tribromosalan and parbendazole composition against adult Fasciola hepatica in sheep. Res Vet Sci. 1981 Jan;30(1):122-3. PMID: 6894647. 19: Condie LW, Buhler DR. Effect of hexachlorophene, tribromsalan, trichlorcarban and cloflucarban on hexobarbital sleeping time and hepatic drug- metabolizing enzyme activity in vitro in the rat. Biochem Pharmacol. 1979;28(3):375-80. doi: 10.1016/0006-2952(79)90101-1. PMID: 426854. 20: Chun Hong HS, Steltenkamp RJ, Smith NL. Quantitative analysis of tribromsalan in blood and urine. J Pharm Sci. 1975 Dec;64(12):2007-8. doi: 10.1002/jps.2600641225. PMID: 1513.