EF-4-177 is a CDK2 inhibitor (Kd= 7.4nM) as Male Contraceptives that Reduce Sperm Counts in Mice. EF-4-177 is metabolically stable, orally bioavailable, and significantly disrupts spermatogenesis, demonstrating this series’ therapeutic potential.
MedKoo Cat#: 122641
Name: EF-4-177
CAS#: N/A
Chemical Formula: C18H14F5N3O2S
Exact Mass: 431.0700
Molecular Weight: 431.38
Elemental Analysis: C, 50.12; H, 3.27; F, 22.02; N, 9.74; O, 7.42; S, 7.43
The following data is based on the product molecular weight 431.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
