MedKoo Cat#: 130025 | Name: Elenestinib
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Elenestinib is a tyrosine kinase inhibitor with potential as an antineoplastic agent. In initial clinical trials, Elenestinib has been shown to lead to rapid improvements in mast cell burden measurements with relation to systemic mastocytosis.

Chemical Structure

Elenestinib
Elenestinib
CAS#2505078-08-8 (free base)

Theoretical Analysis

MedKoo Cat#: 130025

Name: Elenestinib

CAS#: 2505078-08-8 (free base)

Chemical Formula: C27H29FN10O

Exact Mass: 528.2510

Molecular Weight: 528.60

Elemental Analysis: C, 61.35; H, 5.53; F, 3.59; N, 26.50; O, 3.03

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Synonym
Elenestinib; BLU 263; BLU-263; BLU263
IUPAC/Chemical Name
2-{4-[4-(4-{5-[(1S)-1-amino-1-(4-fluorophenyl)ethyl]pyrimidin-2-yl}piperazin-1- yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-1H-pyrazol-1-yl}ethan-1-ol
InChi Key
IPMARPMXSFFZFG-MHZLTWQESA-N
InChi Code
InChI=1S/C27H29FN10O/c1-27(29,21-2-4-23(28)5-3-21)22-14-30-26(31-15-22)36-8-6-35(7-9-36)25-24-12-19(17-38(24)34-18-32-25)20-13-33-37(16-20)10-11-39/h2-5,12-18,39H,6-11,29H2,1H3/t27-/m0/s1
SMILES Code
OCCN1N=CC(C2=CN3N=CN=C(N4CCN(C5=NC=C([C@](C6=CC=C(F)C=C6)(N)C)C=N5)CC4)C3=C2)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 528.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Gotlib J. Available and emerging therapies for bona fide advanced systemic mastocytosis and primary eosinophilic neoplasms. Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):34-46. doi: 10.1182/hematology.2022000368. PMID: 36485158; PMCID: PMC9821059.