MedKoo Cat#: 525779 | Name: Omaciclovir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Omaciclovir, also known as ABT-091 and H2G, is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HSV infection. Omaciclovir is selectively phosphorylated by viral thymidine kinase to its monophosphate form and is further modified to a triphosphate, which is an inhibitor of VZV DNA polymerase.

Chemical Structure

Omaciclovir
Omaciclovir
CAS#124265-89-0

Theoretical Analysis

MedKoo Cat#: 525779

Name: Omaciclovir

CAS#: 124265-89-0

Chemical Formula: C10H15N5O3

Exact Mass: 253.1175

Molecular Weight: 253.26

Elemental Analysis: C, 47.42; H, 5.97; N, 27.65; O, 18.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
ABT-091; ABT091; ABT 091; H2G; H 2G; (-)-2HM-HBG; A-182091; 2HMHBG; Omaciclovir
IUPAC/Chemical Name
(R)-2-amino-9-(4-hydroxy-2-(hydroxymethyl)butyl)-1H-purin-6(9H)-one
InChi Key
SCBFBAWJWLXVHS-ZCFIWIBFSA-N
InChi Code
InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)3-6(4-17)1-2-16/h5-6,16-17H,1-4H2,(H3,11,13,14,18)/t6-/m1/s1
SMILES Code
O=C1NC(N)=NC2=C1N=CN2C[C@H](CO)CCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 253.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bonnafous P, Agut H. Activity of H2G on human herpesvirus-6B strains either sensitive or resistant to ganciclovir. J Clin Virol. 2010 Jun;48(2):153-4. doi: 10.1016/j.jcv.2010.03.019. PubMed PMID: 20395169. 2: Yao K, Hoest C, Rashti F, Schott TC, Jacobson S. Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells. J Clin Virol. 2009 Sep;46(1):10-4. doi: 10.1016/j.jcv.2009.05.014. PubMed PMID: 19524486. 3: Neyts J, Andrei G, De Clercq E. The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil. Antimicrob Agents Chemother. 1998 Dec;42(12):3285-9. PubMed PMID: 9835529; PubMed Central PMCID: PMC106037.