Y08197 | CAS# | CBP/P300 BRD inhibitor

MedKoo Cat#: 122631 | Name: Y08197

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Y08197 is a CBP/P300 BRD inhibitor

Chemical Structure

Y08197

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122631

Name: Y08197

CAS#: N/A

Chemical Formula: C23H21FN4O4

Exact Mass: 436.1500

Molecular Weight: 436.44

Elemental Analysis: C, 63.30; H, 4.85; F, 4.35; N, 12.84; O, 14.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Y08197; Y 08197; Y-08197

IUPAC/Chemical Name

3-acetyl-N-(2-fluoro-5-(hydroxymethyl)-3-(1-methyl-1H-pyrazol-4-yl)phenyl)-7-methoxyindolizine-1-carboxamide

InChi Key

BFOSEOLXWOXFQF-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H21FN4O4/c1-13(30)20-9-18(21-8-16(32-3)4-5-28(20)21)23(31)26-19-7-14(12-29)6-17(22(19)24)15-10-25-27(2)11-15/h4-11,29H,12H2,1-3H3,(H,26,31)

SMILES Code

COC(C=CN1C(C(C)=O)=C2)=CC1=C2C(NC3=CC(CO)=CC(C4=CN(C)N=C4)=C3F)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 436.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Akinsiku OE, Soremekun OS, Olotu FA, Soliman MES. Exploring the Role of Asp1116 in Selective Drug Targeting of CREBcAMP- Responsive Element-binding Protein Implicated in Prostate Cancer. Comb Chem High Throughput Screen. 2020;23(3):178-184. doi: 10.2174/1386207323666200219122057. PMID: 32072894. 2: Zou LJ, Xiang QP, Xue XQ, Zhang C, Li CC, Wang C, Li Q, Wang R, Wu S, Zhou YL, Zhang Y, Xu Y. Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer. Acta Pharmacol Sin. 2019 Nov;40(11):1436-1447. doi: 10.1038/s41401-019-0237-5. Epub 2019 May 16. PMID: 31097763; PMCID: PMC6889168.