Z-DEVD-fmk | CAS#210344-95-9 | caspase-3 inhibitor

MedKoo Cat#: 561669 | Name: Z-DEVD-fmk

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z-DEVD-FMK is a tetrapeptide fluoromethyl ketone inhibitor that selectively targets caspase-3, an essential executioner in apoptosis. By irreversibly binding to the enzyme’s active site, it prevents proteolytic cleavage of key substrates, effectively blocking apoptotic signaling. This compound is widely used in research to study programmed cell death and evaluate anti-apoptotic therapeutic strategies.

Chemical Structure

Z-DEVD-fmk

CAS#210344-95-9

Theoretical Analysis

MedKoo Cat#: 561669

Name: Z-DEVD-fmk

CAS#: 210344-95-9

Chemical Formula: C30H41FN4O12

Exact Mass: 668.2705

Molecular Weight: 668.67

Elemental Analysis: C, 53.89; H, 6.18; F, 2.84; N, 8.38; O, 28.71

Price and Availability

Size	Price	Availability
25mg	USD 950.00	2 Weeks
50mg	USD 1,650.00	2 Weeks
100mg	USD 2,650.00	2 Weeks
200mg	USD 4,650.00	2 Weeks
500mg	USD 6,650.00	2 Weeks

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Related CAS #

No Data

Synonym

Z-DEVD-fmk; Z DEVD fmk; ZDEVDfmk;

IUPAC/Chemical Name

methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

InChi Key

GBJVAVGBSGRRKN-JYEBCORGSA-N

InChi Code

InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

SMILES Code

O=C(OC)CC[C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(OC)=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 668.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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