Boditrectinib is a tyrosine-kinase inhibitor, specifically inhibiting TRKA, TRKB, and TRKC along with preventing mutations of TRKs that lead to resistance. The fusion of TRKA, TRKB, and TRKC with unrelated gene partners has been shown to lead to increased risk of oncogenic activity. Boditrectinib has potential as an antineoplastic agent with the FDA granting Boditrectinib the Orphan Drug Designation.
MedKoo Cat#: 130020
Name: Boditrectinib
CAS#: 1940165-80-9
Chemical Formula: C23H24F2N6O
Exact Mass: 438.1980
Molecular Weight: 438.48
Elemental Analysis: C, 63.00; H, 5.52; F, 8.67; N, 19.17; O, 3.65
The following data is based on the product molecular weight 438.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
