CCRP2 HCl | CAS#958323-31-4 | TLX Enhancer

MedKoo Cat#: 565346 | Name: CCRP2 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CCRP2, also known as TLX agonist 1 and SUN23314, is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity. CCRP2 was reported in PLoS One . 2014 Jun 17;9(6):e99440.

Chemical Structure

CCRP2 HCl

CAS#CCRP2 HCl

Theoretical Analysis

MedKoo Cat#: 565346

Name: CCRP2 HCl

CAS#: CCRP2 HCl

Chemical Formula: C23H27ClN4O

Exact Mass: 0.0000

Molecular Weight: 410.95

Elemental Analysis: C, 67.22; H, 6.62; Cl, 8.63; N, 13.63; O, 3.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

958323-31-4 (free base) CCRP2 HCl

Synonym

TLX agonist 1; SUN23314; SUN-23314; SUN 23314; CCRP2; CCRP-2; CCRP 2; CCRP2 HCl; CCRP2 hydrochloride

IUPAC/Chemical Name

(4-Benzhydrylpiperazin-1-yl)(1,5-dimethyl-1H-pyrazol-3-yl)methanone hydorchloride

InChi Key

CHQPDKRLUPNGDL-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H26N4O.ClH/c1-18-17-21(24-25(18)2)23(28)27-15-13-26(14-16-27)22(19-9-5-3-6-10-19)20-11-7-4-8-12-20;/h3-12,17,22H,13-16H2,1-2H3;1H

SMILES Code

O=C(N1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=NN(C)C(C)=C4.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors. Presently, no natural or synthetic ligand has been identified for a large group of orphan NRs. Small molecules to target these orphan NRs will provide unique resources for uncovering regulatory systems that impact human health and to modulate these pathways with drugs. The orphan NR tailless (TLX, NR2E1), a transcriptional repressor, is a major player in neurogenesis and Neural Stem Cell (NSC) derived brain tumors. No chemical probes that modulate TLX activity are available, and it is not clear whether TLX is druggable.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 410.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014 Jun 17;9(6):e99440. doi: 10.1371/journal.pone.0099440. eCollection 2014. PubMed PMID: 24936658; PubMed Central PMCID: PMC4060991.

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