MedKoo Cat#: 122624 | Name: PB221

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PB221 is σR agonist.

Chemical Structure

PB221
PB221
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122624

Name: PB221

CAS#: N/A

Chemical Formula: C25H39NO

Exact Mass: 369.3000

Molecular Weight: 369.59

Elemental Analysis: C, 81.24; H, 10.64; N, 3.79; O, 4.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PB221; PB 221; PB-221
IUPAC/Chemical Name
4-cyclohexyl-1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl)piperidine
InChi Key
MRPKDJVATMDGCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H39NO/c1-27-25-14-6-12-23-22(10-5-13-24(23)25)11-7-17-26-18-15-21(16-19-26)20-8-3-2-4-9-20/h6,12,14,20-22H,2-5,7-11,13,15-19H2,1H3
SMILES Code
COC1=CC=CC2=C1CCCC2CCCN3CCC(C4CCCCC4)CC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu CC, Yu CF, Wang SC, Li HY, Lin CM, Wang HH, Abate C, Chiang CS. Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor. BMC Cancer. 2019 May 20;19(1):473. doi: 10.1186/s12885-019-5700-7. PMID: 31109310; PMCID: PMC6528305. 2: Pati ML, Hornick JR, Niso M, Berardi F, Spitzer D, Abate C, Hawkins W. Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer. BMC Cancer. 2017 Jan 13;17(1):51. doi: 10.1186/s12885-016-3040-4. PMID: 28086830; PMCID: PMC5237291.