MedKoo Cat#: 471043 | Name: Cyamemazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors with antipsychotic and anxiolytic properties.

Chemical Structure

Cyamemazine
Cyamemazine
CAS#3546-03-0 (free base)

Theoretical Analysis

MedKoo Cat#: 471043

Name: Cyamemazine

CAS#: 3546-03-0 (free base)

Chemical Formula: C19H21N3S

Exact Mass: 323.1456

Molecular Weight: 323.46

Elemental Analysis: C, 70.55; H, 6.54; N, 12.99; S, 9.91

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,450.00 2 Weeks
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Synonym
Cyamemazine; 7204 R. E.; 7204 RP; Ciamatil; Cianatil; Cyamemazin; Tercian; R.P. 7204; TH2602; TH 2602; TH-2602; F. I. 6229
IUPAC/Chemical Name
10-[3-(Dimethylamino)-2-methylpropyl]-10H-phenothiazine-2-carbonitrile
InChi Key
SLFGIOIONGJGRT-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
SMILES Code
N#CC(C=C1N2CC(C)CN(C)C)=CC=C1SC3=C2C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 323.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Vendrell-Criado V, et al. Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment. J Photochem Photobiol B. 2020 Jan;202:111686. doi: 10.1016/j.jphotobiol.2019.111686. Epub 2019 Nov 6. 2. Bourin M, et al. Preclinical and clinical pharmacology of cyamemazine: anxiolytic effects and prevention of alcohol and benzodiazepine withdrawal syndrome. CNS Drug Rev. 2004 Fall;10(3):219-29.