MedKoo Cat#: 556167 | Name: Boc-Val-Cit-PAB-PNP
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Boc-Val-Cit-PAB-PNP is a useful and cleavable linker for ADC (antibody drug conjugate) synthesis.

Chemical Structure

Boc-Val-Cit-PAB-PNP
Boc-Val-Cit-PAB-PNP
CAS#870487-10-8

Theoretical Analysis

MedKoo Cat#: 556167

Name: Boc-Val-Cit-PAB-PNP

CAS#: 870487-10-8

Chemical Formula: C30H40N6O10

Exact Mass: 644.2806

Molecular Weight: 644.68

Elemental Analysis: C, 55.89; H, 6.25; N, 13.04; O, 24.82

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,650.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
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Synonym
Boc-Val-Cit-PAB-PNP; Boc Val-Cit-PAB-PNP; Boc-Val-Cit PAB-PNP; Boc-Val-Cit-PAB PNP; Boc Val Cit PAB PNP
IUPAC/Chemical Name
tert-Butyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate
InChi Key
SKWLDDHVHXQPOG-ZEQRLZLVSA-N
InChi Code
InChI=1S/C30H40N6O10/c1-18(2)24(35-28(40)46-30(3,4)5)26(38)34-23(7-6-16-32-27(31)39)25(37)33-20-10-8-19(9-11-20)17-44-29(41)45-22-14-12-21(13-15-22)36(42)43/h8-15,18,23-24H,6-7,16-17H2,1-5H3,(H,33,37)(H,34,38)(H,35,40)(H3,31,32,39)/t23-,24-/m0/s1
SMILES Code
O=C(OC(C)(C)C)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 644.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Beck A, Goetsch L, Dumontet C, Corvaïa N. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. doi: 10.1038/nrd.2016.268. Epub 2017 Mar 17. PMID: 28303026.