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MedKoo Cat#: 564027 | Name: LLL3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LLL3 is a small molecule STAT3 inhibitor.

Chemical Structure

LLL3
LLL3
CAS#63972-38-3

Theoretical Analysis

MedKoo Cat#: 564027

Name: LLL3

CAS#: 63972-38-3

Chemical Formula: C16H10O4

Exact Mass: 266.0579

Molecular Weight: 266.25

Elemental Analysis: C, 72.18; H, 3.79; O, 24.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LLL3; LLL-3; LLL 3
IUPAC/Chemical Name
1-Acetyl-5-hydroxy-anthraquinone
InChi Key
RROLKYCVTJGMND-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H10O4/c1-8(17)9-4-2-5-10-13(9)15(19)11-6-3-7-12(18)14(11)16(10)20/h2-7,18H,1H3
SMILES Code
O=C(C1=C2C=CC=C1O)C3=CC=CC(C(C)=O)=C3C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 266.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lovewell TRJ, McDonagh AJG, Messenger AG, Azzouz M, Tazi-Ahnini R. Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating STAT1 and STAT1-Regulated Genes. Front Immunol. 2018 Jun 28;9:1380. doi: 10.3389/fimmu.2018.01380. eCollection 2018. PubMed PMID: 30002654; PubMed Central PMCID: PMC6031710. 2: Bhasin D, Etter JP, Chettiar SN, Mok M, Li PK. Antiproliferative activities and SAR studies of substituted anthraquinones and 1,4-naphthoquinones. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6864-7. doi: 10.1016/j.bmcl.2013.09.098. Epub 2013 Oct 9. PubMed PMID: 24176397. 3: Bonham AJ, Wenta N, Osslund LM, Prussin AJ 2nd, Vinkemeier U, Reich NO. STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition. Nucleic Acids Res. 2013 Jan;41(2):754-63. doi: 10.1093/nar/gks1085. Epub 2012 Nov 24. PubMed PMID: 23180800; PubMed Central PMCID: PMC3553987. 4: Fossey SL, Bear MD, Kisseberth WC, Pennell M, London CA. Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. BMC Cancer. 2011 Apr 11;11:125. doi: 10.1186/1471-2407-11-125. PubMed PMID: 21481226; PubMed Central PMCID: PMC3079692.