SC-10 | CAS#102649-79-6 | PKC activator

MedKoo Cat#: 563219 | Name: SC-10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC-10 is a PKC activator. It acts by stimulating PKC mediated myosin light chain phosphorylation without activating MLC kinase.

Chemical Structure

SC-10

CAS#102649-79-6

Theoretical Analysis

MedKoo Cat#: 563219

Name: SC-10

CAS#: 102649-79-6

Chemical Formula: C17H22ClNO2S

Exact Mass: 339.1060

Molecular Weight: 339.87

Elemental Analysis: C, 60.08; H, 6.52; Cl, 10.43; N, 4.12; O, 9.41; S, 9.43

Price and Availability

Size	Price	Availability
5mg	USD 90.00	Ready to ship
10mg	USD 165.00	Ready to ship
25mg	USD 350.00	Ready to ship
50mg	USD 550.00	Ready to ship
100mg	USD 950.00	Ready to ship
200mg	USD 1,650.00	Ready to ship
500mg	USD 2,950.00	Ready to ship

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Related CAS #

102649-79-6

Synonym

SC-10; SC 10; SC10;

IUPAC/Chemical Name

N-Heptyl-5-chloro-1-naphthalene-sulfonamide

InChi Key

MJMJERJFCHYXEM-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H22ClNO2S/c1-2-3-4-5-6-13-19-22(20,21)17-12-8-9-14-15(17)10-7-11-16(14)18/h7-12,19H,2-6,13H2,1H3

SMILES Code

O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCCCCCC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Certificate of Analysis

View CoA: current batch, Lot#A25T02K18

QC Data

View QC data: current batch, Lot#A25T02K18

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

PKC Activator

In vitro activity:

SC-10 crowns showed more microleakage compared to Protemp 4 crowns. SC-10 crowns cemented with Kalzinol showed maximum microleakage and Protemp 4 crowns cemented with HY bond showed least microleakage. Reference: Arora SJ, Arora A, Upadhyaya V, Jain S. Comparative evaluation of marginal leakage of provisional crowns cemented with different temporary luting cements: In vitro study. J Indian Prosthodont Soc. 2016 Jan-Mar;16(1):42-8. doi: 10.4103/0972-4052.164911. PMID: 27134427; PMCID: PMC4832796.

In vivo activity:

	Solvent	mg/mL	mM
Solubility
	DMSO	3.4	10.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 339.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

Arora SJ, Arora A, Upadhyaya V, Jain S. Comparative evaluation of marginal leakage of provisional crowns cemented with different temporary luting cements: In vitro study. J Indian Prosthodont Soc. 2016 Jan-Mar;16(1):42-8. doi: 10.4103/0972-4052.164911. PMID: 27134427; PMCID: PMC4832796. Harnish DC, Liu X, Kenney T, Winneker RC, Chadwick C, Friedrichs GS, Kilbourne EJ. The pathway-selective estrogen receptor ligand WAY-169916 displays differential activity in ischemia-reperfusion injury models. J Cardiovasc Pharmacol. 2006 Jun;47(6):788-95. doi: 10.1097/01.fjc.0000211793.60528.f7. PMID: 16810080.

In vivo protocol:

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Fungal biomass as biosorbent for the removal of Acid Blue 161 dye in aqueous solution. Environ Sci Pollut Res Int. 2017 Feb;24(4):4200-4209. doi: 10.1007/s11356-016-8153-4. Epub 2016 Dec 2. PubMed PMID: 27909927. 5: Sigmundová D, Sigmund E, Badura P, Vokáčová J, Trhlíková L, Bucksch J. Weekday-weekend patterns of physical activity and screen time in parents and their pre-schoolers. BMC Public Health. 2016 Aug 30;16:898. doi: 10.1186/s12889-016-3586-8. PubMed PMID: 27576897; PubMed Central PMCID: PMC5004262. 6: Zhuang Y, Calderon C, Marciniak SJ Jr, Bouman-Thio E, Szapary P, Yang TY, Schantz A, Davis HM, Zhou H, Xu Z. First-in-human study to assess guselkumab (anti-IL-23 mAb) pharmacokinetics/safety in healthy subjects and patients with moderate-to-severe psoriasis. Eur J Clin Pharmacol. 2016 Nov;72(11):1303-1310. Epub 2016 Aug 11. 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