Thalidomide-5-(PEG2-acid) is a PROTAC building block that contains an E3 ligase ligand substituted with carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
MedKoo Cat#: 122203
Name: Thalidomide-5-(PEG2-acid)
CAS#: N/A
Chemical Formula: C21H23N3O9
Exact Mass: 461.1434
Molecular Weight: 461.43
Elemental Analysis: C, 54.66; H, 5.02; N, 9.11; O, 31.21
The following data is based on the product molecular weight 461.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
