XDN87973, also known as (S,R,S)-AHPC-C6-PEG3-butyl alkyne, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
MedKoo Cat#: 121180
Name: XDN87973
CAS#: 2421187-97-3
Chemical Formula: C40H60N4O7S
Exact Mass: 740.4183
Molecular Weight: 741.00
Elemental Analysis: C, 64.84; H, 8.16; N, 7.56; O, 15.11; S, 4.33
The following data is based on the product molecular weight 741.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
