H-7 inhibitor | protein kinase C inhibitor | CAS#84477-87-2

MedKoo Cat#: 556149 | Name: H-7 inhibitor

Description:

WARNING: This product is for research use only, not for human or veterinary use.

H-7 is a specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.

Chemical Structure

H-7 inhibitor

CAS#84477-87-2 (free base)

Theoretical Analysis

MedKoo Cat#: 556149

Name: H-7 inhibitor

CAS#: 84477-87-2 (free base)

Chemical Formula: C14H17N3O2S

Exact Mass: 291.1041

Molecular Weight: 291.37

Elemental Analysis: C, 57.71; H, 5.88; N, 14.42; O, 10.98; S, 11.00

Price and Availability

Size	Price	Availability
50mg	USD 950.00	2 Weeks
100mg	USD 1,450.00	2 Weeks
200mg	USD 2,450.00	2 Weeks

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Related CAS #

108930-17-2 (2HCl) 84477-87-2 (free base)

Synonym

H-7 inhibitor; H 7 inhibitor; H7 inhibitor; H-7 free base; Protein kinase inhibitor H-7; Protein kinase inhibitor H7

IUPAC/Chemical Name

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine

InChi Key

BDVFVCGFMNCYPV-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3

SMILES Code

CC1N(S(=O)(C2=CC=CC3=C2C=CN=C3)=O)CCNC1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 291.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Hidaka H, Inagaki M, Kawamoto S, Sasaki Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41. doi: 10.1021/bi00316a032. PMID: 6238627.