Synonym
TCS-2210; TCS 2210; TCS2210;
IUPAC/Chemical Name
1,2-dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide
InChi Key
ZOFZKGFBKISZRI-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17N3O3/c22-17(21-24)13-9-10-14-16(11-13)19-15(18(23)20-14)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-11,24H,4,7-8H2,(H,20,23)(H,21,22)
SMILES Code
O=C(C1=CC2=C(NC(C(CCCC3=CC=CC=C3)=N2)=O)C=C1)NO
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
TCS-2210 increased expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells.
In vitro activity:
This study identified TCS-2210, which induced a neuronal differentiation from mesenchymal stem cells (MSCs).
Reference: J Med Chem. 2009 Dec 24;52(24):7931-3. https://pubmed.ncbi.nlm.nih.gov/20014867/
In vivo activity:
To be determined
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
5.0 |
15.46 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
323.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Kim NR, Kang SK, Ahn HH, Kwon SW, Park WS, Kim KS, Kim SS, Jung HJ, Choi SU, Ahn JH, Kim KR. Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558. PMID: 20014867.
In vitro protocol:
1. Kim NR, Kang SK, Ahn HH, Kwon SW, Park WS, Kim KS, Kim SS, Jung HJ, Choi SU, Ahn JH, Kim KR. Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558. PMID: 20014867.
In vivo protocol:
To be determined
1. Kim NR, Kang SK, Ahn HH, Kwon SW, Park WS, Kim KS, Kim SS, Jung HJ, Choi SU, Ahn JH, Kim KR. Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell. J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558. PMID: 20014867.
2. Imelio JA, Trajtenberg F, Mondino S, Zarantonelli L, Vitrenko I, Lemée L, Cokelaer T, Picardeau M, Buschiazzo A. Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa. PLoS One. 2024 Sep 26;19(9):e0311040. doi: 10.1371/journal.pone.0311040. PMID: 39325783; PMCID: PMC11426443.
3: Brandau, S., Bruderek, K., Hestermann, K., Görtz, G. E., Horstmann, M., Mattheis, S., ... & Berchner-Pfannschmidt, U. (2015). Orbital fibroblasts from Graves' orbitopathy patients share functional and immunophenotypic properties with mesenchymal stem/stromal cells. Investigative ophthalmology & visual science, 56(11), 6549-6557.
