MedKoo Cat#: 526179 | Name: Ro 24-5098

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 24-5098 is an anti-HIV inhibitory effects of isoddA pronucleotides.

Chemical Structure

Ro 24-5098
Ro 24-5098
CAS#127682-75-1

Theoretical Analysis

MedKoo Cat#: 526179

Name: Ro 24-5098

CAS#: 127682-75-1

Chemical Formula: C10H13N5O2

Exact Mass: 235.1069

Molecular Weight: 235.25

Elemental Analysis: C, 51.06; H, 5.57; N, 29.77; O, 13.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 24-5098; Ro-24-5098; Ro 245098.
IUPAC/Chemical Name
((2R,4R)-4-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol
InChi Key
FJKGKWDFDNULCJ-RNFRBKRXSA-N
InChi Code
InChI=1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)6-1-7(2-16)17-3-6/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7-/m1/s1
SMILES Code
OC[C@@H]1OC[C@H](N2C=NC3=C(N)N=CN=C23)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 235.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pal S, Nair V. Phosphorylation of the anti-HIV compound (S,S)-isodideoxyadenosine by human recombinant deoxycytidine kinase. Biochem Pharmacol. 2000 Nov 15;60(10):1505-8. PubMed PMID: 11020453. 2: Valette G, Pompon A, Girardet JL, Cappellacci L, Franchetti P, Grifantini M, La Colla P, Loi AG, Périgaud C, Gosselin G, Imbach JL. Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates. J Med Chem. 1996 May 10;39(10):1981-90. PubMed PMID: 8642557. 3: Nair V, St Clair MH, Reardon JE, Krasny HC, Hazen RJ, Paff MT, Boone LR, Tisdale M, Najera I, Dornsife RE, et al. Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol. Antimicrob Agents Chemother. 1995 Sep;39(9):1993-9. PubMed PMID: 8540705; PubMed Central PMCID: PMC162870. 4: Franchetti P, Cappellacci L, Grifantini M, Messini L, abu Sheikha G, Loi AG, Tramontano E, de Montis A, Spiga MG, La Colla P. Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs. J Med Chem. 1994 Oct 14;37(21):3534-41. PubMed PMID: 7523675. 5: Frank KB, Connell EV, Holman MJ, Huryn DM, Sluboski BC, Tam SY, Todaro LJ, Weigele M, Richman DD, Mitsuya H, et al. Anabolism and mechanism of action of Ro24-5098, an isomer of 2',3'-dideoxyadenosine (ddA) with anti-HIV activity. Ann N Y Acad Sci. 1990;616:408-14. Review. PubMed PMID: 1706575.