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MedKoo Cat#: 125214 | Name: BD-Oligo

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BD-Oligo is a promising fluorescence sensor for the detection of Aβ oligomer. BD-Oligo enables dynamic oligomer monitoring during fibrillogenesis in vitro and shows in vivo Aβ oligomers staining possibility in the AD mice model. BD-Oligo demonstrated dynamic oligomer monitoring during Aβ fibrillogenesis, as Aβ peptide was induced to form fibrils over time. The sensing process is based on π–π-stacking interactions in addition to H bonding between BD-Oligo and the exposed hydrophobic patches of Aβ oligomers, as determined by computational techniques. BD-Oligo is able to cross the BBB to give rise to oligomers detection in the brains of AD transgenic mice model without toxicity.

Chemical Structure

BD-Oligo
BD-Oligo
CAS#1357578-02-9

Theoretical Analysis

MedKoo Cat#: 125214

Name: BD-Oligo

CAS#: 1357578-02-9

Chemical Formula: C25H24BCl3F2N2O4

Exact Mass: 570.0900

Molecular Weight: 571.63

Elemental Analysis: C, 52.53; H, 4.23; B, 1.89; Cl, 18.60; F, 6.65; N, 4.90; O, 11.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
BD-Oligo; BD Oligo; BDOligo; BoDipy-Oligomer;
IUPAC/Chemical Name
2,2,2-trichloroethyl (E)-3-(7-(3-ethoxy-2-hydroxystyryl)-5,5-difluoro-9-methyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanoate
InChi Key
LTYJVBBHDBFIQG-BQYQJAHWSA-N
InChi Code
InChI=1S/C25H24BCl3F2N2O4/c1-3-36-22-6-4-5-17(24(22)35)7-8-19-13-16(2)21-14-20-10-9-18(32(20)26(30,31)33(19)21)11-12-23(34)37-15-25(27,28)29/h4-10,13-14,35H,3,11-12,15H2,1-2H3/b8-7+
SMILES Code
CC1=C2N([B-](F)([N+]3=C(C=CC3=C2)CCC(OCC(Cl)(Cl)Cl)=O)F)C(/C=C/C4=C(O)C(OCC)=CC=C4)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Aggregation of amyloid β-peptide (Aβ) is implicated in the pathology of Alzheimer's disease (AD), with the soluble, Aβ oligomeric species thought to be the critical pathological species. Identification and characterization of intermediate species formed during the aggregation process is crucial to the understanding of the mechanisms by which oligomeric species mediate neuronal toxicity and following disease progression. Probing these species proved to be extremely challenging, as evident by the lack of reliable sensors, due to their heterogeneous and transient nature.

Preparing Stock Solutions

The following data is based on the product molecular weight 571.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Teoh CL, Su D, Sahu S, Yun SW, Drummond E, Prelli F, Lim S, Cho S, Ham S, Wisniewski T, Chang YT. Chemical Fluorescent Probe for Detection of Aβ Oligomers. J Am Chem Soc. 2015 Oct 28;137(42):13503-9. doi: 10.1021/jacs.5b06190. Epub 2015 Aug 7. PMID: 26218347; PMCID: PMC4756585. 2: Barran-Berdon AL, Ocampo S, Haider M, Morales-Aparicio J, Ottenberg G, Kendall A, Yarmola E, Mishra S, Long JR, Hagen SJ, Stubbs G, Brady LJ. Enhanced purification coupled with biophysical analyses shows cross-β structure as a core building block for Streptococcus mutans functional amyloids. Sci Rep. 2020 Mar 20;10(1):5138. doi: 10.1038/s41598-020-62115-7. PMID: 32198417; PMCID: PMC7083922.