NEP-28 | CAS# 1254176-87-8 | AR Agonist

MedKoo Cat#: 121003 | Name: NEP-28

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NEP-28 is an AR agonist. NEP28 is a new SARM exhibiting high selectivity for androgen receptor. NEP28 showed tissue-selective effect equivalent to or higher than existing SARMs. In addition, the administration of NEP28 increased the activity of neprilysin, a known Aβ-degrading enzyme.

Chemical Structure

NEP-28

CAS#1254176-87-8

Theoretical Analysis

MedKoo Cat#: 121003

Name: NEP-28

CAS#: 1254176-87-8

Chemical Formula: C10H10BrF3N2S

Exact Mass: 325.9700

Molecular Weight: 327.16

Elemental Analysis: C, 36.71; H, 3.08; Br, 24.42; F, 17.42; N, 8.56; S, 9.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NEP-28; NEP28; NEP 28

IUPAC/Chemical Name

3-bromo-5-(propyl(2,2,2-trifluoroethyl)amino)thiophene-2-carbonitrile

InChi Key

OLCJCOHUOJPPBI-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H10BrF3N2S/c1-2-3-16(6-10(12,13)14)9-4-7(11)8(5-15)17-9/h4H,2-3,6H2,1H3

SMILES Code

BrC1=C(SC(N(CCC)CC(F)(F)F)=C1)C#N

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Age-related androgen depletion is known to be a risk factor for various diseases, such as osteoporosis and sarcopenia. Furthermore, recent studies have demonstrated that age-related androgen depletion results in accumulation of β-amyloid protein and thereby acts as a risk factor for the development of Alzheimer's disease. Supplemental androgen therapy has been shown to be efficacious in treating osteoporosis and sarcopenia

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 327.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Akita K, Harada K, Ichihara J, Takata N, Takahashi Y, Saito K. A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate. Eur J Pharmacol. 2013 Nov 15;720(1-3):107-14. doi: 10.1016/j.ejphar.2013.10.042. Epub 2013 Oct 29. PMID: 24177288.