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MedKoo Cat#: 208325 | Name: RGM8-51

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RGM8-51 is a TRPM8 antagonist which is promising pharmacological tool to study TRPM8-related diseases

Chemical Structure

RGM8-51
RGM8-51
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208325

Name: RGM8-51

CAS#: unknown

Chemical Formula: C39H44N2O3

Exact Mass: 588.3352

Molecular Weight: 588.79

Elemental Analysis: C, 79.56; H, 7.53; N, 4.76; O, 8.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RGM851, RG-M8-51, NSC783744
IUPAC/Chemical Name
tert-Butyl (2S,3S)-2-benzyl-1-((S)-2-(dibenzylamino)-3-phenylpropyl)-3-methyl-4-oxoazetidine-2-carboxylate
InChi Key
KSLUNABNSLOTSR-FJAJXMGASA-N
InChi Code
InChI=1S/C39H44N2O3/c1-30-36(42)41(39(30,37(43)44-38(2,3)4)26-32-19-11-6-12-20-32)29-35(25-31-17-9-5-10-18-31)40(27-33-21-13-7-14-22-33)28-34-23-15-8-16-24-34/h5-24,30,35H,25-29H2,1-4H3/t30-,35+,39+/m1/s1
SMILES Code
O=C([C@@]([C@@H]1C)(CC2=CC=CC=C2)N(C[C@@H](N(CC3=CC=CC=C3)CC4=CC=CC=C4)CC5=CC=CC=C5)C1=O)OC(C)(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 588.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Martín-Escura C, Medina-Peris A, Spear LA, de la Torre Martínez R, Olivos-Oré LA, Barahona MV, González-Rodríguez S, Fernández-Ballester G, Fernández-Carvajal A, Artalejo AR, Ferrer-Montiel A, González-Muñiz R. β-Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models. Int J Mol Sci. 2022 Feb 28;23(5):2692. doi: 10.3390/ijms23052692. PMID: 35269831; PMCID: PMC8910920.

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