Synonym
RGH 1756; RGH-1756;
IUPAC/Chemical Name
6-(4-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butoxy)phenyl)imidazo[2,1-b]thiazole
InChi Key
XFCPMLXQURUUPM-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H30N4O2S/c1-31-25-7-3-2-6-24(25)29-15-13-28(14-16-29)12-4-5-18-32-22-10-8-21(9-11-22)23-20-30-17-19-33-26(30)27-23/h2-3,6-11,17,19-20H,4-5,12-16,18H2,1H3
SMILES Code
COC1=CC=CC=C1N2CCN(CCCCOC3=CC=C(C4=CN5C(SC=C5)=N4)C=C3)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
462.61
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gémesi LI, Kapás M, Szeberényi S. Application of LC-MS analysis to the characterisation of the in vitro and in vivo metabolite profiles of RGH-1756 in the rat. J Pharm Biomed Anal. 2001 Mar;24(5-6):877-85. PubMed PMID: 11248481.
2: Kovács KJ, Csejtei M, Laszlovszky I. Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D(3) receptor selective RGH-1756. Neuropharmacology. 2001 Mar;40(3):383-93. PubMed PMID: 11166331.
3: Sóvágó J, Farde L, Halldin C, Schukin E, Schou M, Laszlovszky I, Kiss B, Gulyás B. Lack of effect of reserpine-induced dopamine depletion on the binding of the dopamine-D3 selective radioligand, [11C]RGH-1756. Brain Res Bull. 2005 Oct 15;67(3):219-24. PubMed PMID: 16144658.
4: Terjéki E, Kapás M. An HPLC/UV method for the determination of RGH-1756 in dog and rat plasma. J Pharm Biomed Anal. 2001 Mar;24(5-6):913-20. PubMed PMID: 11248484.
5: Sóvágó J, Farde L, Halldin C, Langer O, Laszlovszky I, Kiss B, Gulyás B. Positron emission tomographic evaluation of the putative dopamine-D3 receptor ligand, [11C]RGH-1756 in the monkey brain. Neurochem Int. 2004 Oct;45(5):609-17. PubMed PMID: 15234102.
