MedKoo Cat#: 128000 | Name: RGT-018
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RGT-018 is a potent and orally active SOS1 inhibitor with anti-tumor effects.

Chemical Structure

RGT-018
RGT-018
CAS#2794934-49-7

Theoretical Analysis

MedKoo Cat#: 128000

Name: RGT-018

CAS#: 2794934-49-7

Chemical Formula: C27H24F3N7O2

Exact Mass: 535.1944

Molecular Weight: 535.53

Elemental Analysis: C, 60.56; H, 4.52; F, 10.64; N, 18.31; O, 5.98

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
No Data
Synonym
RGT-018; RGT 018; RGT018
IUPAC/Chemical Name
(R)-5-(4-((1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)amino)-2-methyl-6-morpholino-7-oxo-6,7-dihydropyrido[4,3-d]pyrimidin-8-yl)picolinonitrile
InChi Key
HRMKBFIINYRRDO-OAHLLOKOSA-N
InChi Code
InChI=1S/C27H24F3N7O2/c1-15(19-4-3-5-20(23(19)28)25(29)30)33-26-21-14-37(36-8-10-39-11-9-36)27(38)22(24(21)34-16(2)35-26)17-6-7-18(12-31)32-13-17/h3-7,13-15,25H,8-11H2,1-2H3,(H,33,34,35)/t15-/m1/s1
SMILES Code
O=C1C(C2=CN=C(C#N)C=C2)=C3C(C(N[C@@H](C4=C(C(C(F)F)=CC=C4)F)C)=NC(C)=N3)=CN1N5CCOCC5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 535.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Xiao F, Wang K, Wang X, Li H, Hu Z, Ren X, Huang W, Feng T, Yao L, Lin J, Li C, Zhang Z, Mei L, Zhu X, Zhong W, Xie Z. Discovery of RGT-018: a Potent, Selective and Orally Bioavailable SOS1 Inhibitor for KRAS-driven Cancers. Mol Cancer Ther. 2024 Aug 1. doi: 10.1158/1535-7163.MCT-24-0049. Epub ahead of print. PMID: 39087485.