MedKoo Cat#: 208324 | Name: Peptide 1018

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Peptide 1018 inhibits swarming surface motility, an important bacterial adaptation associated with antibiotic resistance, virulence, and dissemination of P. aeruginosa.

Chemical Structure

Peptide 1018
Peptide 1018
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208324

Name: Peptide 1018

CAS#: unknown

Chemical Formula: C71H126N26O12

Exact Mass: 1535.0049

Molecular Weight: 1535.96

Elemental Analysis: C, 55.52; H, 8.27; N, 23.71; O, 12.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Peptide-1018, Peptide1018, Innate defense regulator 1018, VRLIVAVRIWRR-NH2
IUPAC/Chemical Name
Val-Arg-Leu-Ile-Val-Ala-Val-Arg-Ile-Trp-Arg-Arg-NH2
InChi Key
RNOHIZCXHRBFRE-MUOSHHONSA-N
InChi Code
InChI=1S/C71H126N26O12/c1-14-39(11)54(66(108)93-50(33-42-34-86-44-23-17-16-22-43(42)44)61(103)89-46(25-19-29-83-69(76)77)58(100)88-45(56(73)98)24-18-28-82-68(74)75)96-60(102)48(27-21-31-85-71(80)81)91-65(107)53(38(9)10)94-57(99)41(13)87-64(106)52(37(7)8)95-67(109)55(40(12)15-2)97-62(104)49(32-35(3)4)92-59(101)47(26-20-30-84-70(78)79)90-63(105)51(72)36(5)6/h16-17,22-23,34-41,45-55,86H,14-15,18-21,24-33,72H2,1-13H3,(H2,73,98)(H,87,106)(H,88,100)(H,89,103)(H,90,105)(H,91,107)(H,92,101)(H,93,108)(H,94,99)(H,95,109)(H,96,102)(H,97,104)(H4,74,75,82)(H4,76,77,83)(H4,78,79,84)(H4,80,81,85)/t39-,40-,41-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-/m0/s1
SMILES Code
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,535.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wilkinson LV, Alford MA, Coleman SR, Wu BC, Lee AHY, Blimkie TM, Bains M, Falsafi R, Pletzer D, Hancock REW. Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa. PLoS One. 2021 Apr 30;16(4):e0250977. doi: 10.1371/journal.pone.0250977. PMID: 33930077; PMCID: PMC8087004. 2: Mansour SC, de la Fuente-Núñez C, Hancock RE. Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections. J Pept Sci. 2015 May;21(5):323-9. doi: 10.1002/psc.2708. Epub 2014 Oct 31. PMID: 25358509. 3: Yin HB, Boomer A, Chen CH, Patel J. Antibiofilm Efficacy of Peptide 1018 against Listeria monocytogenes and Shiga Toxigenic Escherichia coli on Equipment Surfaces. J Food Prot. 2019 Nov;82(11):1837-1843. doi: 10.4315/0362-028X.JFP-19-168. PMID: 31599650. 4: Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D. Autophagy in the physiological endometrium and cancer. Autophagy. 2021 May;17(5):1077-1095. doi: 10.1080/15548627.2020.1752548. Epub 2020 May 13. PMID: 32401642; PMCID: PMC8143243. 5: Andresen L, Tenson T, Hauryliuk V. Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp. Sci Rep. 2016 Nov 7;6:36549. doi: 10.1038/srep36549. PMID: 27819280; PMCID: PMC5098146. 6: Lemon DJ, Kay MK, Titus JK, Ford AA, Chen W, Hamlin NJ, Hwang YY. Construction of a genetically modified T7Select phage system to express the antimicrobial peptide 1018. J Microbiol. 2019 Jun;57(6):532-538. doi: 10.1007/s12275-019-8686-6. Epub 2019 May 27. PMID: 31054139. 7: Choe H, Narayanan AS, Gandhi DA, Weinberg A, Marcus RE, Lee Z, Bonomo RA, Greenfield EM. Immunomodulatory Peptide IDR-1018 Decreases Implant Infection and Preserves Osseointegration. Clin Orthop Relat Res. 2015 Sep;473(9):2898-907. doi: 10.1007/s11999-015-4301-2. PMID: 25953690; PMCID: PMC4523515. 8: Etayash H, Pletzer D, Kumar P, Straus SK, Hancock REW. Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity. J Med Chem. 2020 Sep 10;63(17):9228-9236. doi: 10.1021/acs.jmedchem.0c00303. Epub 2020 Aug 18. PMID: 32787088. 9: Yang Y, Xia L, Haapasalo M, Wei W, Zhang D, Ma J, Shen Y. A novel hydroxyapatite-binding antimicrobial peptide against oral biofilms. Clin Oral Investig. 2019 Jun;23(6):2705-2712. doi: 10.1007/s00784-018-2701-x. Epub 2018 Oct 23. PMID: 30353289. 10: Cheng AYY, Patel DK, Reid TS, Wyne K. Differentiating Basal Insulin Preparations: Understanding How They Work Explains Why They Are Different. Adv Ther. 2019 May;36(5):1018-1030. doi: 10.1007/s12325-019-00925-6. Epub 2019 Mar 30. PMID: 30929185; PMCID: PMC6824364.