Synonym
Actisomide; Actisomidum; SC 36602; SC-36602; SC36602;
IUPAC/Chemical Name
(4R,4aR)-4-(2-(diisopropylamino)ethyl)-1-methyl-4-phenyl-4,4a,5,6,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidin-3-one
InChi Key
QAHRRCMLXFLZTF-FYYLOGMGSA-N
InChi Code
InChI=1S/C23H35N3O/c1-17(2)25(18(3)4)16-14-23(20-11-7-6-8-12-20)21-13-9-10-15-26(21)19(5)24-22(23)27/h6-8,11-12,17-18,21H,9-10,13-16H2,1-5H3/t21-,23-/m1/s1
SMILES Code
O=C1[C@@](C2=CC=CC=C2)(CCN(C(C)C)C(C)C)[C@](CCCC3)([H])N3C(C)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
369.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mahmood I. Prediction of clearance, volume of distribution and half-life by allometric scaling and by use of plasma concentrations predicted from pharmacokinetic constants: a comparative study. J Pharm Pharmacol. 1999 Aug;51(8):905-10. PubMed PMID: 10504028.
2: Cook CS, Rozek LF, Stolzenbach J, Anderson S, Schoenhard GL, Karim A. Pharmacokinetics of a novel antiarrhythmic drug, actisomide. Pharm Res. 1993 Mar;10(3):427-33. PubMed PMID: 8464818.
3: Cook CS, Rozek LF, Hribar J, Schoenhard GL, Karim A. Metabolism of actisomide in the dog, monkey and man: a novel rearrangement of N-dealkylated metabolites. Eur J Drug Metab Pharmacokinet. 1992 Apr-Jun;17(2):145-54. PubMed PMID: 1425813.
4: Malesker MA, Mohiuddin SM, Destache CJ, Stoysich A, Dean RR, Hilleman DE, Sketch MH Sr. Pharmacokinetic and tolerance evaluation of actisomide, a new antiarrhythmic agent, in healthy volunteers. DICP. 1991 Mar;25(3):231-4. PubMed PMID: 2028626.
