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MedKoo Cat#: 592587 | Name: Pentisomide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pentisomide is an Anti-Arrhythmia Agent.

Chemical Structure

Pentisomide
Pentisomide
CAS#78833-03-1

Theoretical Analysis

MedKoo Cat#: 592587

Name: Pentisomide

CAS#: 78833-03-1

Chemical Formula: C19H33N3O

Exact Mass: 319.2624

Molecular Weight: 319.49

Elemental Analysis: C, 71.43; H, 10.41; N, 13.15; O, 5.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pentisomide; Pentisomidum
IUPAC/Chemical Name
alpha-(2-(Diisopropylamino)ethyl)-alpha-isobutylpyridine-2-acetamide
InChi Key
ZZOZYGHXNQPIPS-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H33N3O/c1-14(2)13-19(18(20)23,17-9-7-8-11-21-17)10-12-22(15(3)4)16(5)6/h7-9,11,14-16H,10,12-13H2,1-6H3,(H2,20,23)
SMILES Code
O=C(N)C(CC(C)C)(CCN(C(C)C)C(C)C)C1=NC=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Olsson SB, Edvardsson N, Newell PA, Yuan S, Zeng Z. Effect of pentisomide (CM 7857) on myocardial excitation, conduction, repolarization, and refractoriness. An electrophysiological study in humans. J Cardiovasc Pharmacol. 1991 Dec;18(6):849-54. PubMed PMID: 1725897. 2: Kühlkamp V, Mewis C, Seipel L. Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia. Int J Cardiol. 1992 Jul;36(1):69-79. PubMed PMID: 1428255. 3: Hachisu M, Chen H, Soneda T, Fujishima K, Ishizuka T, Konno F. Antiarrhythmic effect related to the plasma concentration of pentisomide in vivo and the antiarrhythmic-concentration relationship in vitro. Drugs Exp Clin Res. 1995;21(4):145-51. PubMed PMID: 8529527. 4: Holt DW, Walker S, Johnston A, Jones RW, Howse NL, Darragh A, Caffrey E. The effect of age on the pharmacokinetics of pentisomide. Biopharm Drug Dispos. 1991 Nov;12(8):627-31. PubMed PMID: 1801967. 5: Vergara G, Inama G, Guarnerio M, Rando F, Oldani V, Furlanello F. Electropharmacological test with pentisomide (CM 7857) in patients with sustained ventricular tachycardia. G Ital Cardiol. 1990 Jun;20(6):543-8. PubMed PMID: 2227224. 6: Endou M, Hattori Y, Gando S, Kanno M. Selectivity of class I antiarrhythmic agents, disopyramide, pirmenol, and pentisomide for peripheral muscarinic M2 and M3 receptors. J Cardiovasc Pharmacol. 1992 May;19(5):674-81. PubMed PMID: 1381764. 7: Plomp TA, Buijs MJ. High-performance liquid chromatographic method for the simultaneous determination of pentisomide and its major metabolite N-desisopropylpentisomide in plasma, urine and tissues using solid-phase extraction. J Chromatogr. 1993 Jan 29;612(1):123-35. PubMed PMID: 8454692. 8: Inoue H, Yamashita T, Usui M, Nozaki A, Saihara S, Sugimoto T. Effects of pentisomide and E-4031 on canine atrial flutter due to reentry: a comparative study with disopyramide and propafenone. J Cardiovasc Pharmacol. 1991 Jul;18(1):137-43. PubMed PMID: 1719282. 9: Mangini SG, Mastropasqua F, Oldani V, Massari F, Maino GN, Ricci A, Scrutinio D, Rizzon P. Evaluation of pentisomide on stable ventricular premature beats. Comparison with placebo. Eur Heart J. 1991 Jun;12(6):712-9. PubMed PMID: 1713557. 10: Mewis C, Kühlkamp V, Lindena I, Risler T, Ress K. Quantitation of pentisomide and its metabolite by high-pressure liquid chromatography in human serum. J Chromatogr Sci. 1996 Apr;34(4):161-5. PubMed PMID: 8901131. 11: Ni Y. [Effects of oral pentisomide on ECG and hemodynamics]. Zhonghua Xin Xue Guan Bing Za Zhi. 1990 Dec;18(6):365-7. Chinese. PubMed PMID: 2093559. 12: Adornato E, Pennisi V, Catanzariti D, Pangallo A. Acute and chronic electrophysiological effects of pentisomide on the sinus and AV nodal function, noninvasive evaluation by a pacemaker with temporary pacing inhibition. Pacing Clin Electrophysiol. 1992 Nov;15(11 Pt 2):2127-9. PubMed PMID: 1279612. 13: Kühlkamp V, Mewis C, Mayer F, Seipel L. [Electrophysiologic effects of penticainide in patients with supraventricular tachycardia]. Z Kardiol. 1990 Oct;79(10):725-31. German. PubMed PMID: 2087860. 14: Nakaya H, Shishido Y, Oyama Y, Kanno M. Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs. J Cardiovasc Pharmacol. 1992 Jan;19(1):140-7. PubMed PMID: 1375681. 15: Endou M, Gando S, Hattori Y, Kanno M. Binding profiles of class I antiarrhythmic agents to cardiac muscarinic receptors: competitive and allosteric interactions with the receptors and their pharmacological significance. J Pharmacol Exp Ther. 1991 Sep;258(3):992-8. PubMed PMID: 1890628. 16: Hanaki Y, Sugiyama S, Hieda N, Taki K, Hayashi H, Ozawa T. Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts. J Am Coll Cardiol. 1989 Jul;14(1):219-24. PubMed PMID: 2738264. 17: Endou M. [Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors]. Hokkaido Igaku Zasshi. 1991 Sep;66(5):677-93. Japanese. PubMed PMID: 1959843. 18: Pfisterer M, Munoz A, Burkart F. Hemodynamic effects of penticainide (CM 7857), a novel class I antiarrhythmic drug--comparison with disopyramide. J Cardiovasc Pharmacol. 1988 Aug;12(2):247-51. PubMed PMID: 2459557. 19: Yamashita T, Sugimoto T. [Medical management of arrhythmias; newer antiarrhythmic drugs]. Nihon Rinsho. 1991 Nov;49(11):2680-6. Japanese. PubMed PMID: 1685198. 20: Li JY, Northover BJ. Antiarrhythmic and electrophysiological effects of amiodarone, lignocaine, and penticainide in anaesthetised rats. Cardiovasc Res. 1992 Nov;26(11):1116-20. PubMed PMID: 1291090.