MedKoo Cat#: 534659 | Name: Ioversol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ioversol is a Diagnostic Aid (Radiopaque Medium).

Chemical Structure

Ioversol
Ioversol
CAS#87771-40-2

Theoretical Analysis

MedKoo Cat#: 534659

Name: Ioversol

CAS#: 87771-40-2

Chemical Formula: C18H24I3N3O9

Exact Mass: 806.8647

Molecular Weight: 807.12

Elemental Analysis: C, 26.79; H, 3.00; I, 47.17; N, 5.21; O, 17.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ioversol
IUPAC/Chemical Name
1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((hydroxyacetyl)(2-hydroxyethyl)amino)-2,4,6-triiodo-
InChi Key
AMDBBAQNWSUWGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H24I3N3O9/c19-13-11(17(32)22-3-8(29)5-26)14(20)16(24(1-2-25)10(31)7-28)15(21)12(13)18(33)23-4-9(30)6-27/h8-9,25-30H,1-7H2,(H,22,32)(H,23,33)
SMILES Code
O=C(C1=C(I)C(N(C(CO)=O)CCO)=C(I)C(C(NCC(O)CO)=O)=C1I)NCC(O)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 807.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Ioversol. 2018 Oct 31. PMID: 30000462. 2: Tan Y, Zheng S, Lei W, Wang F, Jiang S, Zeng T, Zhou B, Hong F. Ethiodized poppyseed oil versus ioversol for image quality and adverse events in hysterosalpingography: a prospective cohort study. BMC Med Imaging. 2019 Jun 24;19(1):50. doi: 10.1186/s12880-019-0346-0. PMID: 31234782; PMCID: PMC6591817. 3: Wang H, Li T, Zhao L, Sun M, Jian Y, Liu J, Zhang Y, Li Y, Dang M, Zhang G. Dynamic Effects of Ioversol on the Permeability of the Blood-Brain Barrier and the Expression of ZO-1/Occludin in Rats. J Mol Neurosci. 2019 Jun;68(2):295-303. doi: 10.1007/s12031-019-01305-z. Epub 2019 Apr 7. PMID: 30955191. 4: Quirós C, Cillero AI, Bretaña L, García M, Prieto B, Álvarez FV. In vivo interference of Ioversol in serum and urine capillary electrophoresis: an optimized protocol for sample collection. Clin Chem Lab Med. 2018 Jan 26;56(2):e53-e55. doi: 10.1515/cclm-2017-0509. PMID: 28771431. 5: Hammerbeck AA, Daniels NH, Callen JP. Ioversol-induced acute generalized exanthematous pustulosis: a case report. Arch Dermatol. 2009 Jun;145(6):683-7. doi: 10.1001/archdermatol.2009.100. PMID: 19528424. 6: Scott H, Palmer FJ. Ioversol in ascending phlebography--a clinical trial. Australas Radiol. 1990 Feb;34(1):44-6. doi: 10.1111/j.1440-1673.1990.tb02806.x. PMID: 2192700. 7: Vogl TJ, Wessling J, Buerke B. An observational study to evaluate the efficiency and safety of ioversol pre-filled syringes compared with ioversol bottles in contrast-enhanced examinations. Acta Radiol. 2012 Oct 1;53(8):914-20. doi: 10.1258/ar.2012.120303. Epub 2012 Sep 14. PMID: 22983259. 8: Morales-Cabeza C, Roa-Medellín D, Torrado I, De Barrio M, Fernández-Álvarez C, Montes-Aceñero JF, De La Riva I, Prieto-García A. Immediate reactions to iodinated contrast media. Ann Allergy Asthma Immunol. 2017 Dec;119(6):553-557. doi: 10.1016/j.anai.2017.08.014. Epub 2017 Oct 7. PMID: 29017901. 9: Oldroyd SD, Haylor JL, Morcos SK. The acute effect of ioversol on kidney function: role of endothelin. Eur J Radiol. 1995 Jan;19(2):91-5. doi: 10.1016/0720-048x(94)00579-2. PMID: 7713094. 10: Suh YJ, Yoon SH, Hong H, Hahn S, Kang DY, Kang HR, Choi YH, Lee W. Acute Adverse Reactions to Nonionic Iodinated Contrast Media: A Meta-Analysis. Invest Radiol. 2019 Sep;54(9):589-599. doi: 10.1097/RLI.0000000000000568. PMID: 30998567.