SF2535 is a PI3Kδ/BRD4 inhibitor. Previously, combination of BRD4 and PI3K inhibition with SF2523 was shown to successfully decrease Myc expression. SF2535 significantly downregulates both c-Myc mRNA and protein expression through inhibition of BRD4 at the c-Myc promoter site and decreases p-AKT expression through inhibition of the PI3Kδ/AKT pathway. SF2535 induced apoptosis in B-ALL by downregulation of BCL-2 and increased cleavage of caspase-3, caspase-7, and PARP. Moreover, SF2535 induced cell cycle arrest and decreased cell counts in B-ALL
MedKoo Cat#: 208274
Name: SF2535
CAS#: unknown
Chemical Formula: C20H19NO5S
Exact Mass: 385.0984
Molecular Weight: 385.43
Elemental Analysis: C, 62.32; H, 4.97; N, 3.63; O, 20.75; S, 8.32
The following data is based on the product molecular weight 385.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
