ML-077, also known as VU0255011, is a highly selective, potent, saline soluble, "best in class" KCC2 antagonist for high fidelity in vitro studies on KCC2 function with IC(50)=537 nM. ML-077 is cell permeable and exhibits submicromolar potency, and shows greater than 10-fold selectivity over other closely related NKCC transporters.
MedKoo Cat#: 555370
Name: ML-077
CAS#: 1135304-61-8
Chemical Formula: C17H16N4OS2
Exact Mass: 356.0766
Molecular Weight: 356.46
Elemental Analysis: C, 57.28; H, 4.52; N, 15.72; O, 4.49; S, 17.99
The following data is based on the product molecular weight 356.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |