YH149 | CAS#unknown | Ligand

MedKoo Cat#: 208262 | Name: YH149

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YH149 is a highly promising PET probe for visualizing MAGL non-invasively in vivo and holds great potential to support drug development.

Chemical Structure

YH149

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 208262

Name: YH149

CAS#: unknown

Chemical Formula: C25H24FN3O3

Exact Mass: 433.1802

Molecular Weight: 433.48

Elemental Analysis: Chemical Formula: C25H24FN3O3 Exact Mass: 433.1802 Molecular Weight: 433.4834 Elemental Analysis: C, 69.27; H, 5.58; F, 4.38; N, 9.69; O, 11.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

YH-149, Y-H149, YH1-49

IUPAC/Chemical Name

(R)-1-(4'-Fluoro-[1,1'-biphenyl]-4-yl)-4-(4-(furan-2-carbonyl)piperazin-1-yl)pyrrolidin-2-one

InChi Key

HVVLTSHAUJYILM-JOCHJYFZSA-N

InChi Code

1S/C25H24FN3O3/c26-20-7-3-18(4-8-20)19-5-9-21(10-6-19)29-17-22(16-24(29)30)27-11-13-28(14-12-27)25(31)23-2-1-15-32-23/h1-10,15,22H,11-14,16-17H2/t22-/m1/s1

SMILES Code

FC1=CC=C(C2=CC=C(N3C[C@H](N4CCN(C(C5=CC=CO5)=O)CC4)CC3=O)C=C2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 433.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

He Y, Schild M, Grether U, Benz J, Leibrock L, Heer D, Topp A, Collin L, Kuhn B, Wittwer M, Keller C, Gobbi LC, Schibli R, Mu L. Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. J Med Chem. 2022 Feb 10;65(3):2191-2207. doi: 10.1021/acs.jmedchem.1c01706. Epub 2022 Jan 28. PMID: 35089028.