D-δ-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage. It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM. D-δ-Tocopherol decreases capillary formation of HMEC-1 blood endothelial cells. It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. D-δ-Tocopherol reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells. Dietary administration of D-δ-Tocopherol reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model.
MedKoo Cat#: 463118
Name: D-δ-Tocopherol
CAS#: 119-13-1
Chemical Formula: C27H46O2
Exact Mass: 402.3498
Molecular Weight: 402.66
Elemental Analysis: C, 80.54; H, 11.52; O, 7.95
The following data is based on the product molecular weight 402.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
