Synonym
Kansuinine A; Kansuinin A
IUPAC/Chemical Name
(1S,2S,3aR,4R,5R,7R,9S,10S,11S,13R,13aR)-10-(Benzoyloxy)-4-hydroxy-2,5,8,8-tetramethyl-12-methylene-6-oxotetradecahydro-3aH-4,7-epoxycyclopenta[12]annulene-1,3a,9,11,13-pentayl pentaacetate
InChi Key
VKHCUWUNVKZFBM-PNKWBUBPSA-N
InChi Code
InChI=1S/C37H46O15/c1-17-16-36(51-24(8)42)26(28(17)46-20(4)38)29(47-21(5)39)18(2)30(48-22(6)40)31(50-34(44)25-14-12-11-13-15-25)33(49-23(7)41)35(9,10)32-27(43)19(3)37(36,45)52-32/h11-15,17,19,26,28-33,45H,2,16H2,1,3-10H3/t17-,19+,26+,28-,29-,30-,31+,32-,33+,36+,37+/m0/s1
SMILES Code
O=C1[C@@]2([H])C(C)(C)[C@H](OC(C)=O)[C@H](OC(C3=CC=CC=C3)=O)[C@@H](OC(C)=O)C([C@H](OC(C)=O)[C@]([C@@H](OC(C)=O)[C@@H](C)C4)([H])[C@@]4(OC(C)=O)[C@@](O2)(O)[C@@H]1C)=C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
730.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ma H, Yang S, Lu H, Zhang Y. Bioassay-guided Separation of Anti-tumor Components from Euphorbia kansui by Means of Two-dimensional Preparative High Performance Liquid Chromatography and Real-time Cell Analysis. Anal Sci. 2016;32(5):581-6. doi: 10.2116/analsci.32.581. PubMed PMID: 27169660.
2: Shu X, Jiang XW, Cheng BC, Ma SC, Chen GY, Yu ZL. Ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry analysis of the impact of processing on toxic components of Kansui Radix. BMC Complement Altern Med. 2016 Feb 24;16:73. doi: 10.1186/s12906-016-1039-7. PubMed PMID: 26912002; PubMed Central PMCID: PMC4765025.
3: Chang JS, Lee SW, Park MH, Kim MS, Hudson BI, Park SJ, Lee WS, Rho MC. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010 Oct;76(14):1544-9. doi: 10.1055/s-0030-1249805. Epub 2010 Apr 8. PubMed PMID: 20379953.
4: Chen YL, Yuan D, Xu X, Fu HZ. [Studies on macrocyclic jatrophane diterpenes of Euphorbia kansui]. Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(15):1836-9. Chinese. PubMed PMID: 19007010.
5: Yamaguchi K, Tsuji T, Uemura D, Kondo K. Cyclooxygenase induction is essential for NGF synthesis enhancement by NGF inducers in L-M cells. Biosci Biotechnol Biochem. 1996 Jan;60(1):92-4. PubMed PMID: 8824828.
